آناستروزول
Anastrozole
![](data:image/jpeg;base64,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)
موارد مصرف اناستروزول:
Anastrozole در درمان سرطان پستان پیشرفته و به صورت درمان کمکی در مراحل اولیه سرطان پستان و در زنان یائسه با دوز یک میلی گرم در روز به صورت خوراکی تجویز می شود. در بیماران مبتلا به بیماری های فاقد گیرنده استروژنی پاسخ درمانی غیر متحمل است. درمان کمکی می تواند تا 5 سال تداوم یابد اگر چه طول مدت درمانی بهینه غیر مشخص است.
مکانیسم اثر آناستروزول:
یک مهار کننده قوی و انتخابی غیر استروئیدی سیستم آروماتاز (سیستم سنتز استروژن) می باشد که آندروژن های آدرنال را در بافت های محیطی به استروژن تبدیل می کند.
فارماکوکینتیک آناستروزول:
Anastrozole به سرعت و تقریباً به طور کامل از مسیر گوارشی جذب می شود و اوج غلظت پلاسمائی آن طی 2 ساعت حاصل می شود. غذا باعث کاهش سرعت جذب می شود اما این مورد از لحاظ بالینی مهم نمی باشد. Anastrozole به میزان 40% به پروتئین های پلاسما متصل می شود. در کبد متابولیزه می گردد و از طریق ادرار دفع می شود که عمدتاً به شکل متابولیت ها می باشد. نیمه عمر حذف نهایی آن حدود 50 ساعت می باشد و غلظت های پایدار آن بعد از حدود 7 روز در بیمارانی که روزانه یک دوز دریافت کرده اند حاصل می شود.
عوارض جانبی آناستروزول:
شایع ترین عارضه جانبی حاصل اختلالات گوارشی است از جمله بی اشتهایی و حالت تهوع و استفراغ و اسهال، گر گرفتگی، سر گیجه، خواب آلودگی، سردرد و راش های پوستی. از دیگر عوارض جانبی می توان به نازک شدن موها، خشکی واژن و خونریزی، ادم، تنگی نفس، درد عضلانی و درد مفاصل، شکستگی های استخوانی، تب، افزایش وزن، لوکوپنی و سندرم شبه آنفولانزا اشاره کرد. در بعضی بیماران اختلال در مقادیر آنزیم های کبدی، ترومبوآمبولی و افزایش کلسترول تام دیده شده است. موارد بسیار نادری از سندرم استیون- جانسون مشاهده شده است. مصرف این دارو در زنان غیر یائسه (به ویژه در افراد حامله) ممنوع است.