آرسنیک
Arsenic
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موارد مصرف آرسنیک:
به عنوان داروی ضد سرطان در لوسمی حاد پرومیلوسیتیک APL مصرف می شود.
مکانیسم اثر آرسنیک:
از طریق تغییرات مورفولوژیک و تکه تکه کردن DNA، سلول های APL را دچار آپاپتوز می کند. همچنین پروتئین اتصالی PML-RAR alpha را دچار آسیب می نماید.
فارماکوکینتیک آرسنیک:
توزیع: Vdss: آرسنیوس اسید: 562L؛ با افزایش وزن بدن افزایش می یابد.
متابولیسم: آرسنیک تری اکساید بلافاصله به فرم فعال آرسنیوس اسید هیدرولیز می شود که آن هم به متابولیت هایی با فعالیت کمتر متیله می گردد.
نیمه عمر حذف: 10 تا 14 ساعت؛ متابولیت ها تا 72 ساعت.
زمان رسیدن به پیک: در پایان انفوزیون 2 ساعته: 10 تا 24 ساعت.
دفع: ادراری
عوارض جانبی آرسنیک:
قلبی عروقی: تاکی کاردی (55%)، ادم، QT interval >500 msec، درد قفسه سینه، هایپوتنشن، هایپرتنشن، فلاشینگ، رنگ پریدگی، تپش قلب، ادم صورت، ECG غیرنرمال، دیس آریتمی شریانی، torsade de pointes
سیستم عصبی مرکزی: خستگی (63%)، تب (63%)، سردرد (60%)، بی خوابی، اضطراب، سرگیجه، افسردگی، درد، تشنج، خواب آلودگی، آژیتاسیون، کما، گیجی
پوستی: درماتیت، پروریت، کبودی، خشکی پوست، اریتم، هایپرپیگمنتاسیون، پتشی، ضایعات پوستی، کهیر، پوسته پوسته شدن موضعی
اندوکرین و متابولیک: هایپوکالمیا (50%)، هایپرگلایسمی، هایپومنیزمی، هایپرکالمی، هایپوکلسمی، هایپوگلایسمی، خونریزی بین دوره ای قاعدگی، اسیدوز
گوارشی: تهوع (75%)، دل درد (58%)، استفراغ (58%)، اسهال (53%)، گلو درد، یبوست، آنورکسیا، کاهش اشتها، افزایش وزن، دیس پپسیا، اتساع شکم، تندرنس شکم، هموراژ گوارشی، اسهال خونی، تاول های دهانی،گزروستومی، کاندیدیازیس دهانی
ادراری تناسلی: هموراژ واژینال، بی اختیاری ادراری
هماتولوژیک: لوکوسیتوز (50%)، سندروم تمایز APL، ترومبوسیتوپنی، نوتروپنی، DIC، هموراژ
کبدی: افزایش ALT، افزایش AST
موضعی: درد، اریتم، ادم موضع تزریق
نوروماسکولار و اسکلتی: خشکی بدن، آرترالژی، پارستزی، میالژی، درد استخوان، کمر درد، پا درد، گردن درد، ترمور، ضعف
تنفسی: سرفه (65%)، دیس پنه، اپیتاکسی، هایپوکسی، پلورال افیوژن، سینوزیت، ترشحات پشت بینی، عفونت مجرای تنفسی فوقانی، خس خس سینه، کاهش صدای تنفسی، هموپتزی، ادم ریوی، رانشی، تاکی پنه، نازوفارینژیت
چشمی: تاری دید، خارش چشم، خشکی چشم، ادم پلک، چشم دردناک
گوشی: گوش درد، تینیتوس
کلیوی: نارسایی کلیوی، اولیگوریا
متفرقه: هرپس سیمپلکس، دیافورز، عفونت باکتریال، هرپس زوستر، لنفادنوپاتی، عرق شبانه، بیش حساسیتی، سپسیس
تداخلات دارویی آرسنیک:
منع مصرف همزمان: Artemether, Clozapine, Dronedarone, Lumefantrine, Nilotinib, Pimozide, Quetiapine, Quinine, Tetrabenazine, Thioridazine, Toremifene, Vandetanib, Vemurafenib, Ziprasidone
آرسنیک غلظت / اثرات این داروها را افزایش می دهد: Clozapine, Dronedarone, Hypoglycemic agents, Pimozide, QTc-prolonging agents, Quinine, Tetrabenazine, Thioridazine, Toremifene, Vandetanib, Vemurafenib, Ziprasidone
غلظت/ اثرات آرسنیک با این داروها افزایش می یابد: Alfuzosin, Artemether, Chloroquine, Ciprofloxacin, Ciprofloxacin (systemic), Gadobutrol, Herbs (Hypoglycemic properties), Indacaterol, Lumefantrine, Nilotinib, Quetiapine, Quinine
هشدار های آرسنیک:
منع مصرف: بیش حساسیتی
احتیاط:
• در نارسایی کبدی یا کلیوی احتیاط شود.
• QTc را افزایش می دهد. داروهایی که QT را افزایش می دهند قطع کنید. اگر QTc>500 msec در ابتدا وجود داشت، قبل از آغاز درمان باید اصلاح و دوباره چک شود.
• ریسک سندروم تمایز APL و هایپرلوکوسیتوز وجود دارد. در صورت بروز سعلائم APL دوز بالای استروئیدها (دگزامتازون IV 10mg/kg q 12hr حداقل 3 روز داده شود تا علائم فروکش کند.
• می تواند عوارض جنینی ایجاد کند؛ از روش های کنتراسپشن موثر استفاده شود.
• حین درمان، غلظت های پتاسیم بالای 4mEq/L و غلظت های منیزیوم بالای 1.8mg/dL برای جلوگیری از اختلالات هدایتی قلب حفظ شود.
• آرسنیک تری اکساید یک عامل کارسینوژن انسانی است؛ بماران را از نظر بدخیمی های ثانویه چک کنید.
• پروفایل الکترولیت، هماتولوژیک و انعقادی بیمار و ECG را قبل از شروع درمان چک کنید.