آزاسیتیدین
Azacitidine
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o/iAAqcjWMGsAiW22c0aNGsYxjGAAMYxijIkxMNcAgwmJEfwrlULdEf4RqVH8IAFSkfpjXUxIAA10058uXPnz011xrjGpiYa1jUxMBHEJxkR/Bxpj+EalR/AABU5E+cg0KxjH0znOfoT9cYIMaB+sZQkR9c7bbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbZ/UalR94AFSMj9MYEQPaPWRKOPtExkR5NNb8n5Pyfk/J+R8n5Pyfk/I+R8j5Pyfk/I+R8j5HyPkfI+R8j5HyPkfI+R8j5HyPkfIi9Mv1GpUfcKAAJkcEYAAEF24TNch+kiQ8gYxExOPBp/nGuPIhyx4xyK/xwq2o/qNSo+4DxI/QCoVGRnKuRURjABAH1x6seJAgUAB4xE58Gn+IhaTbNSfClQtyhqJRiFICZIan8UKtqP6jUqPtAAAJJ+wIlECOJ1MCJH4oiKpJkKlHA+wPg0/xEpYDcVOlxUubIPIctKwJvW1q2x8YxjWgDHwBpjXFQq2o/qNSo+0eZn75Bizr1Mj4JA1MQDEj7ij9IFcpBw8EfUjyaf5XJJuanVsBVxNc1FkVxYWztp1dChSllASUyStMkNhALRxKShsKjVtR/UalR9goeCZn1CoQCyuUSIDEqyKMDD0ABZXhcgWA+w0/yukVc1OrSjVxUKRU6hTqZVvUKu/Aq3qRLlyYA6BuhbLxN62mrjxGrb9kqPsFCjUpE+qAiPEo85DpKeRKMzKR+6xGJgyIMWlp9hp/ldIq4qdWxFXEFwUGyVJgdC2hV0aFW9NqRt6eQUVc1a02mhAFXHiFW1H9RqVH2ChUySPTnMZwaJZMjNkyfOc+hdAktJ8Z9hp/ldIq4qdLklk1xQS9iWRM0rW5jJUKt6bUqt6fQpFXVWzAZpgo1ceI1bfrNSo+wUKYTQ9WcwlCRlNhYZffOfqJBvWUyfe/zAruGvPhToXBe24lKJVcC4lcNf4FKbN5KnMfldw50aW03MH1c+I1bfslR9g8NIIoGj9M5zmgYMLTLPjPpx+DH1f9M58iW+fGdjL6ZzWc1nKKCp2ykMk6dRq2/ZKj6zQ8NNA5BP3iDHQgeIQmqRyDnOQfAIIJ+58ZJBz4Bon6P/bGS7oXUrpjyajVt+yVH1mhWWA0CCCPGSaxgVmJkBEhVMYyIAH2BFZzWCPABgYGgBHABFZrHl4MdddddddddddddddddNdddddNdddddca6aaRjbD9cqPqP0YTQFAAGJjgREBHXUREZCtiaxj64EBEggUPGuoHgxwKIJrGBWfMl8OHDhw4cOHDhw4cOHDhw4cOHDhw48OHHjw4cOHDjwCYj9cqPrxgiQCwrkFCAgV8gvTTXXXBjKBjpppppoYaGMYxEhgRENdQMa64xrqQYaaa66/4SVH1xiIcuQVz56aa4111111xrqYc+XPnz58+fLly00589ca64xjGMYxjGMY1/wkqPrhQFY++c7gmQnWc7Zzms5znO21Z2rP5CenQS9ZmJf0JUfWJhob1LO0Wg+DTWi4LYuk2EiTPfcsgwMiWHoZ9Ou4ZAsnFkmrl+R1SfFndLfTOrh9o3+hKj6pVIg5JjUykw8mrkZWHBYFGiK0kFgRBJkAdTEGQgZ0TlH5WhwSWm0HgmVwLiLJP+QLna8jZmVyGh8T/MlR9RAUEcOAVJK1AeDU1m25QTNUFmJhGAjOEIaCM4mBhGJjzxGLIRVJS6Bz+JlXFRlA28aFXrrYuilzZrE6RO9q0FyLdi4QH8yVH1wIlnbJIlsZ7g4bMXECRiseMY8YdUrhMskvah5ERczW8tg+BI/A4ukmLFWz23aW38LI3M0BpRK4q2N6bA3aVTQD/NlR9RrcS36Bm0pdDLokmr6cJ2k6332oyE9hRrq0G0xO5Q1yEIFdLmSqC428KMt80WCXrbGVqtLgyaIJUxZt+MEMt4W87eCW26UTkELH82VH1GhAQ0KwNSsKKwqEZG5lwsZuLWG4RNjWXAdC5gy5uQyMy+bGFMput23D5Pky3oyi1jZP62733Bap6p+sFknMFskrZRNE+M0KcZut4/zpUfUagRWDWgGMa4p0pzL0MhVwqK1Kup26nW4DJRpVvcQNRgyFum5jb1eG1S9CBOl02lqdbqq4KRpbD2SHCMJphH0yBt4j+dKj6pVEifWTItk0MDe3aJu2QUbOS0tuXQmpz1wnO4iStkF3TGSqFMq2q7q2q8Sprri3M6XTaTT6WHpQwTQP8AFyo+o0ARgx1wYkYiIFykpIbbBM7f4i0FbLYWotYRdbi2CjbRVO3XBqVJmudqLVdsVRRJMEzhFElztl28R/i5UfXAa89OfPny5cxGRbcomRjGMVghj1NIxjDHQcBWKxjFYnLvAkVjH+MlR9cZxnuD97icAiBO3jOanVxC1BOcyq4iiIonPjILWQuGUIJBO1Zzn/FSo+qVErOVH7GrySZKa64FypzWG6jcLMqfJMnXHyhcra6SpSZO5jcqbOTLldw5sWRaJwm24Fwhzmm5XcQl6c5/vSo+o1GEV6QH3vIJVOlhluljpYShUWVeVbG8pKmQtp3BSXuFGFsx7oBVs5UYFQosAnbWzHyUoC2J9Eyy5FypnraxLvuxsG/pkZPXP1yo+o0sj1XVWlXMbabnwDAoKhU6vKtqu6tBdVbU+lC4ioSiiNzFElNeVCdSqUYSncJi0WgbVtR9D6YEW4g26VdFxvEslTbmF33i+T3TU1V3JjLtVzK4Dp3Fw23bO4F3B07oXi3NuIXYa26XdzdB87gvldquI1OTLpd0XG7XdlrLsMtvZKj6pUJhkZ+h8LdTFut4qt7d6lKh4nVyq3XcqtoXCkruKRTUGO1qtyWotxOK1Tjyip6IqtUPUhU0pifQ+n0mUmBblFiEJU6mUqLIqplQpCWLncQt/hsEKkGLSpynUmQgbeEjKosgqaTO2F1UwKStYcGQyDbqMJMWgqtvZKj6iNIwiB6MYoxCqI186YMMamF3VsY1JQTipQCsa41ogKrGMel9TFui5UqV1PWxoUymDYyXJk4VaMuZyUhs7htRmSylsuHOCaUWHEQBKCJumIW87mUSwKYk3MtyBVjTalFLZztvZKj64ARxWc/XO2c7ZznOc5znOSWpWgHOfOftn2uqS0yaWrhGcLUBrJsEI8pwgsQMFwmtkVLasxXBkec1yC4QhMQWyEBGDILhKBgFyXKlLXJ9GAgI2wnAQlCC0D1yo+o1GcW7iRn1DC2EvDWd+/bv379+/fv379+/fuLg3EGj82fMgVc+ZSEcuPPmUhHLhw5FARzKAkq4ceXHiEceXLkU8OZSEc+ARy4BPPlw4cuXHlwCIR9cqPqlWIA1AzoCZiVmjT6iOREYFWAow8Z+mfCaH5jP64xjGMYxjGMYxjGMYxjGMYxjGMYxjGMYxjGMYxWMYx7pUfUahEL1ETDTkVQjRp9RqImIA1zFSEwBppoQIGBFJoflmZM8zJas4pjIOxj048Y84/FiRlcKl+GVH1rofTH0NP8AC6NSpdYmYU2kiQMQCsABgpND8r5Sn5bUjBpuY3F21DZXEbguFyHhxaHMuF3EnG5XcTabmD5ODe8n/JWypODexf8AIg1jxcwmQxwuYuncfJDmG3dBveJ9pqUvXCh6n+FmZicdACWFNMkZRlmohtGk0Py3bDLy+pyMhE00KhclC2BhjLaTDOUlmbFRXJjjCMyxcpTbIVbUadJZMpShUZMZOrSbKczSLDLVcpUApyzEe1sunrgQc5znOfBp/gTJjMtyGyZQkZmYkJQOWGkkfkkbuQ+j6Z4XTqnSjeUmntYFBwWZwWAtgtKlWAWUBAkyhMWradSznUjqROFtF3gkhdGo0ahGZtIEew1ctUfUaiYyMugaW9oMHg0/3AhpaTSaH4xTi+Q+jqnExgGxkMMEC8SpAeFLlGQSWQthrNcpKg2AMIsphtYCdzEGETRK1MgZW9Tm+AlBYiajExUXVaUT6xTpvYj1mgBEiUQMYWB5nDjw48ePHjx48ePHjx48ePFax+S5JAh5nUl89OepQEipLFuIEBdSRFJiIcyDbRhKPxgowFsBsY/GCiv40YyWLasyj8cRMNefJhgpUY+yRunE2/shERMOfHlyEfLWi7W/6zPyVnGMYxjGMfjnJ0wAPXjFYxjHjGMYxjFYxjGMYxjGMYxjGMYxijCMPYBctbOrf2Q9dyJStlYZcRuDdC6LphNwLiEj+klzPAH98CcrlxNW/sh67ohanRbMSAAjEmpLthCP6WFhozDP8BdtZLxb+yHrmqap1aCaQg2/DgUSKFfqcZ+JgD+8A6dw3zb+yHr3mfjLXWMYqQkpcPOMYxjGKwRWMYrP3dUvBAh/eFXbpHyj2Q9Rp7Es69RItDZNL4NMwzox8WhhYGdOnUM3LYzJ6loaxy2j7Grhgl4H94C4Y9n0R7Ieo1ciMWTTOmTDesiGwnNgdI7hxbF0nRf0L4uY21m4yaWxZOVvQ+oDS+cZCeQf7pN44n6IoeuHqNNjITiiEiwGAiRzWGiETE1qIGBgFgShATjbBxlEQEJC3EfqKuZyrXMCB/cAuWsn9UUPXD1yhz4ctCnhw4BBRxFuVfHCOPEpCeHEW5TFMocOHI261fWRuGQGpXCI+pPSpNg0nuD6STcRYWCX1LAffKcWYwZxn9pG8b9kUPWv1ynGcnQZnOc5z98Yx9iyMvRcSbNY8j6Grh6XTYxi2zuQbV1FnfuHbG4DavHYWSVSLg4y7yY1qpdxLFdN95Oi0zDwSQwzdNBk+DrmdnP65unSIWF8+fPmkD1w9Rp8g2TFsLfkC4NwLk3MbidzC4LjcqdKZebj5JuIXG0nm5FyWB63D7CrthMJA+AfJFyhMW0kXIWYwt6BuG7bwZK4zbtXV8tTwJzLpMW2dwJJcwMeZ2zoTbOTWNFxJqZPuN7Zrj2Lw1bX1BrJWVD6SY26nKMPssetfqNXAEJRUG1GJhzMIwlDEBImKKnUjRBpMZCQZGMAGRtoj6imSuJ0DFgaWifkVcVCmUmrulVEo8NGIxaKSF0mnMagTMqhFoFIjAMppiuC5eWiEWJi1hKraMhcRgTBZdMxlVl9GvY3PoX7F+ua+JRFElBHIqKAoqlbhMrcogo1JARw4hOZJ48SqS0Q+oq7bM/UDyKeIRnCVAFAbarkGxIiJxKyy3K6vB3EeesAyPMNSWBqgUAJYlwM1icowmra3FXcFQZERmJCUbICjTmzn6l0PWv1mW/SU4nGNddSM0I6aaY000056aaaFWASRLww3LPqKH1kArE7daJQ+LBZJVyCSlsZVbKhTIG0Wgp4BJS0EWyuElG2WqjTLcWoTO2VbsSLWEKmuKZLCZ2wtimCxTmMn610PWv13BhNkuqZzabmNwbiDnTiwTD43HeVxFwuIMMupfG4k6DzMvLe0npJoC5YyX1FA/hnA261eicDbrV+eRfP2LoetfruBAOpYTTqlUTlJYK32MoynISE1ynLpOYmWIM6lOJnIG2o0TdNxrrpz5BIV/WfJh+5JmJieVketfrnHlJMrda2QkkpnG3E4yUEBMkSiIhHFS5qmqKuPBK5xkjlJIQqBLKnbi1FqLYW3xvjhHL+tck+ics52E0yHrX7cEYrBjNK1Y566mM0rQIlYFFfPmYCFa41184x4znP9i59BqcSMeEVH1w9u3sxj6Z/xdz6SCsrKzFIj6hUPYwhgPiTRcRkT2jInpnfJn1EqJk6LaLO3UH/AAYq5o+whYHqFQ9jZgJlTZOYoJFy0utHXEpPW+TVze4PVcrbc3Emwcl7yWoksH8mc/XPUNzW2+a32rbbO++ceDPpms7bbGXqJuXA+xdD1CoEHPokW1lcolgepMlsuiIIk8sEGQkumiCHRSx5tLe6TaFy5RtVflkYH6Tm+7L4XFu1k3XQu7Zzi25VdxY967mb5XfzIXyLqn3U7sXKbyDrh/zPmG8Q0D0CrtzJLl7F0PWCJCRn06if0bKFMEILkyTrgSWWzAgZsIahYXTzC4JSi5Wm7a+1Xcu2Tcrn+NjOgMD4jV0WFYWlK7qczi0Y6n1EofcSRTKnUEzUhkrhzIrNthDWqlbmlxtU+gBkrp1AwmD6l0PXGOmpEhhdDyaZAw0IWDFltC14fGFvK15fGKjaxUy2+Gu2jFqZ2arQLnb/AA42sB+IlwoNSzwC+DkgquFOupri5VvIyuKAjKU0UypVZQvVxoyq0gxVxFNJq6lVogD0Crt0j4BjMTzn7roeoVDxjUx5iH0xrroI/wAqRFTU1dvKBoBs5TaMqY2a5NYspa8pW1JpFMqdWr7l8BJMhbundOYgb3DY0l8X/cU5lwzwImNAiYYGBgl9F0PUKgQf68iST0ZSFxNCrkGjUVc5QUidvJSSyFtFqmqTCcWQA0t7eSno1zFaUvkYiGbah9yb10jURGMoSiR4zkSgfK6HryJhgnvtnOc5/h5znO2xnv5I1KykJCxEeJwna/EhbSR8ZaZLnbRtjarQYzt4W5SbX4kbWCqYmdoLRdrznbi0+J8RaPu9jmeIRAoxlAxx4AWPK6HtHgEHOc5ztnbO22dtttttttttttttttttttttttttts5znOck+7JozEjIHznxnPnP0x9j95G7d4iIjzgxKyvnGAHmFD2gUABjGMYxjGMYx+rGMYxjwfdKQZlhXMzjPoJlnQMkzpGYnmTBIs3LYsLAwzDCwN22+1y1s/C4/fGPrCh6zQI8RofziSfa3xCpjmSDWc1kRMQYnJMvGZCAJBJFEwE5pP1nK6b4gIj3Loes1kEGJB/lZJJJJz7JQCQDEAqK4qKwsqChAr5BQE1BZUFFXOcIKKgoKC2RTH63bpy8LHvXQ9ZoneMxITDBMSzn9uc5ztsZGRkZlhbvn25+ufOfXqB9NPoA5ly3zGUWA+1dD1mpAjPUODg8XAuBcdxcd+/cODMmfQM6dN9+nTp069OvUt69upaXdi4u7denQsMzLIAj/PJunE/UTDAzb0mS5R9hBiYFRUYYrIlnOdthKLA+TTPbfp169Om++++2c5oEk1jBHjPjGogI1n+dcMdP0CQmGBm++++5YZmSTD2kEeMa6FfPTTXXXGPpgjGMYxjGMYxjGKxjGummgjismZnWv82Rumk+zOds58pqHuIMSMZztnPtxj6Y+2MYxWSTMz32oRiuK9Ntttttttttttttttttttttttts7ZznbbbO222222222wk9jRpppppppppppppz58+fPnoFpWB7sGJiYGGmmuMY+2c59uc5yTmsa8wsLCxARxW2222222222222222222222222+++++++++222222222286KuXLlx48eXHjx48ePHjx48ePEKEfx4xjGNdddddNNNNNNdddddddddddddddNNNNNNdcY/1uMYxjGMYxjGMY/8ADf8A/8QALBABAQACAQIGAwADAAMAAwAAAQACERASIQMgIjFBUTBAUBMjYDJhgUKAoP/aAAgBAQADPwBnhnlmZmeWZmZmZmZmZmZmZmZmZmZmZmZmZmZmZmZmZmf7OLP3ZfZfbB5iIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiIiP/7GHl/5dnlmZmZmeGZn9ciILFuqMLCMuDGGCxYguq1b4Cxj3sSMoxjKMe9jlyYxlwW/6yzMzP6LMzMzMz+Xs2eOTbxmzbxfeR1lOXYvGvE3ptY2WXtZkpZlmYystmeLqUiy+LIsks5JeMmcctX3BjLab02bldj+ruCP2yIiLX4+zbWcLcbsehnqdT12HT7kdbemItFu9PHqvXu7T1WyLUMRdDGRB4kylqZ1O7Yf9F2lzeMiyCz1rdt2zj3LP7surbbxnGVmZ1JayttqJJZsh4ZyssZyeDU27tO7X9Tvdv4Xb8hEQ2JBGVjBwMEQQxBDa4GIiIYIYORg4P6ve7cEREREREREREREREREf9VptRHmZmZmZ8rMz5iIiP8ApWfuyspmZnzMzMzMzMzZWVlZTP3M27f/AHpERHPf+MR5jzGMNuI/4/v+cLAsG3+nq063KxlieTonquvydmyFs3MtYiyLplbqD/nO1qepkS6v09ll1Nn1Ha1gX+Nuq6iWz6vaTyelu7est4ll1Nlv2tB/x3f82sXjbabTbx3wERY2NvjHGxY97GHjViWLDYPxeGfEBP8AknfvHSWD7l4f1YnscGNgWOQ3vesuxeG+5eH9QWJYtiWEZ+3JjYFgxl/yOsW2yzjdOVvw7WLZC2dnZ2eVo73SOmzbMs+mz3OUYklmtnslLPHJs1JPCGcstsll1asiz3OUYk2bZk5l6y1iWRk2az0lkZWdmlnZDGeJGA2St4mV4uNkMZH8kiIj8JER+trjqyiLWV2C9LdWTaN2pyytF04y5M52ycLuXYtbJybr46L1N6i6/BLoyuq+bpvVaC1OWTddonB1esvSXqbuXpL1W22XRab0E7tsBFrLjZ/x2sbbd4xjK72sy2RYmy6ngMZt5w2PSdrHTeq9JPVbY0RAXqb1EPhkf5L1R0HHqb0nHqsekjpYFvWXpL1N3L0l6rbHQceq/wBZeu22adm8SykS7f2SIiP0dY28pbL6svqcbpzuvGMMZyyu8Yh3h+bqJM7pjpLd6i7ErOLai6i9TeovQX+y9V6Dj1W8SZMm6btOa3rL0l6m73oL1Xe9Bx67eBPVaysNHew+43b/AI7MzMzJMzMzMzMzM8P6GhmXK3GotSMmEpLJM7Lqx4cbKXvOy1q6hkZxslOFyZ6i9BL4kjegtz1cdRIslllM9ZeklyZG9JLlI3pLc9VoLrGRZxsmyybR/F7cb8x+fV3/AEurjp5M+HAnLya+LUZcnT7cdMWOXGoxjKD4tGrrdwXSXVH1dPBlwEJ7QPtwZQfHAwfFqMoumGxy+OcT4g/jhYxERyRERERyRz3/AEyxPmH5/OEP4CP0NR9w/wBBJ3PLKyHlZmfP3u36OoxlfeXL3t4/l1juCMsrZ5zAhyjM/OYDd4z/AJ/bjv5Oq1HT59yklry9/wBLWMuU5NkWjl/Fvw2z3ZdcmPm7Nn3suskOXzM2oxfeMm6rJ3Z79rIeWfO/xNFu78MwWIFjr3h35gsOn3vDzle1me5+sdF64sen44LE+bF+Yfk5Psj7I+yPs8mGfyWGD7lqPsj7IPksfuH54xzLAfcg4D5LE+bF+Y5D5sT5h+Y1epu53jR3jKw+yD2twfNjj8xY5fMcB82L82J8kWOXz/C2+TeoYuiZZmZmZkmHGPJq7/odnhWcfmyX3gxXjNf/ACvE+5Pdscy0WQveT3Z+7LLP3tnGsFsx7Nm5+89C2Q+9l92T82e//Lgyxssd6bNyDquosccZXs3iP/5XiYvfLgyIwL6bNfez6zvPSd5WSy372XR72e//ACnJIwL6bNfez+7M+YQhLI3Z/dm/Nn92QnePED+EW+NWo1GXkIiIiPq1Zfdl5dP6HZ403Va76ujFJyyZztE4smQW8b1Mtll8Ti+1o4/1t3v9l/rbu222XRJlbwePWWsZ2kKbvD1eGXS29TK3XA28bpbfHTi3qu5aElyuuAnBkyLeLe9tjOMC0/w14Ij8pHBHkT9A6b1wsGF3t5R0WLiwLa8Qt4//AC7ttI0doOf9bd7/AGX+tu7byjpePVejj/YXo/8Al623ZSzucZ6r1Fj0ERq9Td40XZvVx3u9j0kdLHe9d6eN5ER03e7/AMHf7Ixa/P6b18eg41lABGm6llzLWP8A8u7dy7Hk/wBbd7/Zf6273qvS8eq9PH+wt4//ACTJgS8PV4ZYbh41laAjd1F3b1F2L3vVdyWTK1GrqlztY3veou16bvd/3w/fH8u8Z6pvQRkMiurLGzbLJ9uNYyrIl2PJ6GVnrv8AWzuTK9DLPV7SYXa9ZdoRZwfazPizy+LJ12tRkM4r2ssfizcjtemVZE7XYlnftIkZYtqyxfazficviC0S7kyO1olxnftI/uhal8j+3q3b/H1Ftum0cGXxzqMbd1XTa8mzV13S7u2rqultF13e6MXj1nAxlyY/EHBn8catF1Wrpurjo4M/jkILd1Wm6bri6P3NcLzqPKcERERERH59/oFj+n2ePWeQjykfjP4muN+RngjhmbKzsrKysrKynza4XhmZngf4fZuqTM7XSf8ABM+UiIiI/KeTUlv+Hi+5YfUf3jgiI/TI/Acah8+NjY2NjY2NjY2NjYWFjY2FhYWFhYWFjY2FhYWFjYWFhYWFhYWEf1mzsp/afOkJ5e04zMzMzMzMzyzMzMzMzMzMzMzbbq/q74CP3NefVvydnyMz5FspOVspP1PV/WN2MS2TNr+DrydudwxGJd+OqLG1JLDY2LdPx+n6v67DERHB+nuGLX5ezzqIbteq6kgCMYYyLvd4xxgYyhxbpfI8PCycrMzz6v7a+Tf6WmOO/wCXt5HdvG7Xqt2sSdzu2W202sZ6p3bw572+CLvEfV0s5PBEB7WuPV/YZnyPBqI3DH4tzMnAkXf8nbyd703a9XHpL1Xe7HPpu96r0c+rjWNpuqAW03UR1W2McbTdVvHjver+yRzuIx4fzEWrU2/y9nyd703a9Vq3iXed2gtNtt4zud2sOfVx6Z6jh6Weq9Jevj0WW7Ld6OO96v5vf8mo5IifIz+Mjhn8vbyd703a9V0pCEZQRiXe7xljCxjBi3U8erj03qOPS3qvSXe0xljC2ON6eO96v7rMv50mbf6HbyabpLqLbw4sMW7qtWognJ573TbLbdN1F3tF1yMlqcm3jx3u5/N7/m1xv+J28rPkyLP7l5bP7s358rPDPDNh82KdiyWcYxxtvHc/k9/z74bInhyZxLT+M/W7P7zjZHLlb47/AMnv+dJ43yYkMe/4WZ8rPkZeT8HaZmZmZmZmZmZmZmZmZmZmbKymZndr+R3/AAsz5nyaJ/Hr8GvJr8g2P1Y/Vj9WP1Y/Vj9WP1Y2Nj9WP1Y/Vj9WP1Y/Vj9WP1Y/Vj9WP1Y/VjY/VjY/Vj9WP1Y/VjY2P1Y2Nj9WP1Y/UY/yO8zZMzP5WZspmZmbKyspmynlnhmfxP8AyO+CIiIj8pERwRwRHJH/AE5+AiGCHgiIiOCIiIjk/X1Y2Nix+PEh/uhERxqG35Ol4WT3ZbK7TuZmUnqhOHczMzuHG1eqLb+qhJlqWRus/FonHK68v7ruZmZGbtz2lZG2TvtwebtaykLdp43a5Qt2pnf6o42s7HVt7WV2ODGx9rHcNiWNjGWN67WdiZahhdW/7O/Nq15N2/iyCX3k9rO7TueFeO92mZ4Z4OFytfEDEfp+m9dmW8u9j08E4T4mc4OyybKUnGXEvVbzssfEtkudo/skRERERFvgwIctbhIYPNrnd04z1WywjU4WWVsicbJyZMbJbZ+lrG3nGU4O7WMBdZK2vEjTb3ajp59V67eCzjlbxH+1pu3k2Wpnjd2vTPWO7ePBEcBD8xbgi68Zcr/Hid7Wd1l1nvdN2gfeEe9626sLTdJEfZDwEP5MsizWzxsTCR0Wfit0Y2PiFlhkpeJk94xPayybLEs8rLGzzbLw8tw+GjbytYH9pUnUzO51ZMzxq0N1qWRh1Wp/x7Lxh97xfuzyTbdBZqg3jHzZuRB4Ys9WsW8ZfezMO7O/eycZ6rxCzMfeWMMbxcs+zeL8suU44WS2Rj73ib7N4v3K6YB03i5rpszLSxmflQs8lNTkb1ZeC+0542rf4NFn19Orf9sjUREFjERxoZ/yM/49XSxngWJuMsrHHDc2OeVgYMY5kngF1+IbbDQ7gwvWQ4kf5IcbRemWwbAtZN6LvemMsrELXiTub12sfy7hd6sQ9ofYnH8W7eW9Rj/b02jyvBDbLU+Jm2ZjPh5FrAtrayhNXV3v8eV1Y6t5F1+CT4eZBdeF6y9Jeu9LypPh5XVbyvRd703qLtb8SfeMF3GWf/Mu51PVMjM2VlN2jNsMHdikLaLq+ItPtCRwDaxCxybv7Xp1G/aAhy3q6SMrp+IzI6ojF9rZahIH2tkGW9Q430WneoP+Y9o1ERHBEcGJO9TlickeQC6br4OC6bq8pHBF03e6uT/mgYSLf4NTn4rawtR5DjtZOUjHBdrJshO92gjyDdNtnIsuu0RHJH/Lu57TP4U8SOj34YyPe1wvzbu1iMXRlx394yx94jfvGJw794z+YxN8KyjJldocoC02UZ3TMr73UfiI/pH7O21xr8PX4mp8PBJ8VunDc49reMuc2r03qnRf7JznBnptknDllJI3+ufEZtW8pMZM5CfE8STBZwzbeO5zGcMreP4dED72/m6vyGMZ5a/AYRk/tBBlq6v2DtGo/Ef57eLY4ZO7Bw0TkkmJDnYh7celvVx/ti97temZnqtELJhYY+9gwjHVHQXrlIw8TvYOCE5ZraxjpY6m9P4fRbz73hPulh4fsziyveDHe53OcBJZLxu183WM4ZqS5A2Ie9kNs7tr5tlqUkyJCz3GWG92rLcZHvdPtZLCe8ntKwfN1ZaunPUB72W7LK2XSWRK970ruysnPTAe9lOWf7KJOpX8Ll8WWPib1GWGrLF7F4j26bRPwWRl7Xbj02Tl7SBZPi/+MhL8WRj7XaFIyLxPDe2LeLl26WyPeM8LLHLtjZj7MuHtZD7S4+1l1+0JJkoWa+0EuwJxxZcva0fh9F6rKen3nxGfCxGXwvey8R3ucAvQyLbZPmdzelnxPEbLwvFl0bsvFs8CyPmeiVnpJciT5tE/4nvZZvvZGO5xx95Zn7svEbLw8py+Z/yz/lsnH3n2m0Wy1Iz/AI2fEWcPFn23ObOGf7K5E6JMvwkfXGOXwWJ8QfEMfXkxfiD4sX4gh+IMXtw9RCWL8WJ8WJ8cY5fFifER9RY/UWL8FifEERY/Ufh9FvOwSAYw1uM8AJPD47Xpbw3cmXayfexPexfa9LY4+K7jPxO1kNjhrdimhu9iYQvaekgZUj/GN/qbvei2WnvYJHxGGUZNkWOPiQ+MWOjdhrZZDKEk5e8X+pu+V/tZXcYxln+yMaiIjzFjEREREREREQkZxi+0ft7xvXu6YyJGcveP8erotEZYskuUambWLOOSy+IMJItuNTvjeJPVw5Y6tYatNvDUatSsdMjLkRqTOcshu0+3BiXUSMtrBLoW34m46WRZ6rR+xpOd2p53y4zuZmZmZmZmZmZt3b9rc2VlbtTJZWUtqeXjVlbkl4SeHhmZl4bdqy5eEsrLlkmeU/YdzOvIzvy7Z1u1LJMsn5O37eMRwRERweQ4I4I4IiOCIiOSIiOSOCIiI4P2R51yPGvJrKHC7wEPAQ2rczMyzJz2/V0Xd8mi9VuIjCMnXB+I5PMfiPIclq03Xjv9/sfj73ou96JjV3u0W4I1drbaLdq78dj9XV3fJ6b1RjEXpnrIIWAiNRBEDCwRGTAQMJBDHVqCNxmcA6hIgIhgiMjgxjcJBEZDPU2sYyjr6bf7nb8feDC7wmoIhjG3z6eC2SHHfjt+rry+ieqZWccgt4F6pxyCXvq02pcZJZJynFlxnPc4eJK6lnGVmf8AJZc+lk8VnpZ3ZatzjLnJqW1gzkpIdUhOUhuS3JjuScvHtH5tW8vymoiIiPL3ktyS8JLxq3OrVu7QHk7fqaxfN6L1cG7/AGF6COuHxMIPDxdR1643att6LfGo6W/2s9ZHTby4Lfiwl/j7w3pv9jHQ3qYcbpt9reZe1rK/1trNj/Fx3jo534C3Tk28h/No43l+TTx2teTfl7+R4fPq1bt89j9TWLbfL6Z6ptS5lvEsjxJzzGOgL/ZuXgZMofDnBslm0Mvit82c5e9qzGyct2ZdRqQI6Z2pZlktkEsrOLZKWgWHFLW0s/a2Wm9MzB4CMdUGBb/KGLK3c/I7nhmZnyb4ZmZmZmZmbKZspLt+o9LKz5Nk/U/U/Utl9W++p+rI+Gc/jhx+Jfhk+LL203X8Th7EvxOPxPvqyfi38Tj8Tl8cOPxOXxd96ssewWf02WXxw4/Evxxlj8Tn8WrI7abP6Zz9y071J8T9T9M/U/VniIFn4j3LLEDX5TE42/lIiIjjXkcJ3dXBEWMY8GeO4jgiIj9UC6vOWNjY2MWNj9WP1Y2P1Y/UfVj9RH1H1H1H1Y/URH1EfUfUWP1H1H1EfUfUR9R9RY/VjY/VjY2P1YxY2L8WGPxY/l1jLlx3P2PVqydZbtEHbgjcZkisYYaYbf7WuF/4MxxZd2/2WycowOnd1jpsut3fVnwluTDcsGJ+1qVeNR/wGrVtf2uu6Ddk+JdoYjnVrHp40ft9+X/gDHC6n9vE948Q0R76nHyEcZOdr9M/AXfgY/v6vct+Tufro3qiPu7bg+Y+41IwxuItZX/uPuD5h+Yj7iIg+YytR9x9x92pyb0+bWPG3/gjDGcsv2+1vKQ3JObawJGZZknK6ZZWSZkmZkeG2WsZGWZePR5tYtttP/A6xbdvy9z9feUdMt0sdFtmZlum3PVaJmZmeHc3ptFvCVnh49Pm0N1MyTdv73Rik5ZP7o24gmGIiIiB4Ijk5C3dNuI4GMfNotrwa415tRwYxlaNxb/FqBjIgt+YHVv9AxjJ5MYy8/Sbt5fvAwwRlEREREREREREREREEMRHm6cbeXJ5tWRZ5Nrw7xMntZ4e9vC8Vdy5aeMcfe8P7vDsGxDd4f3YPs8ON4uXcvEx7Nkwe94ZYMBu8OxTtZHjBaO9huxy9uNWNjY2GNhl7Njj73hvzD7QWNjq37T1WGNhlZG0lPMFrGyzZnyMn6+mz3ZrZlmFlP3P3MzNvhnJtctolygJ6218yvvZM4zldvN243lEcEeTcN0t/rt2sbeUdDa8ZvRNl797L/3ZYz0WWXfvPVq3hwj0pY549V0zqyX5ssZcGzy+5cum/wBo3SE/+U2Ke8a953JjZBPiTi7ldTj3thMmTLjMrKz4d1+Hu7XbyGPDm2v3e1t4S3axuqfJo4edZ2xtLbLUpHUbvTHXLlz3LvdvN0jbyeNSfg7N6r/Xx6b13ob/AHt/qYWx6fax+oDjDoe0f5HVrw7D5LZ1Y2eHZbq4x+oDscYOD2g8V1eqXUuMheL8Nnru3e9EJJYBq6s+0oSW8W6VlgjHOxytX+q7XbjUE5fMv8Dq43JKScMzNkyFktlOLKWS2UzIzqyctzMysnn1byfN28qjZdVvwrPB0Fl4nZJwx3q8Q7T17bXhtluemysm1jZYmred/rsh7XidOrLPvZFlZWSWsN2WO7edk+JOjtZBqyysWDGyxexZ5GrMLJ97LLP2ssX2su0oXaZ2SFl1WRlZOrL/ABzrgLU5P8IIsd6sD5hiIiLEsPuwhiLGwiIiIiIsbEiCHkxwtvn7eXcF21GTGMOOo3GNstxEWsZZ67WMZ3eMSIiLWM/U9cb3Dd4x43GXGi3GLGXHScGUFuIXcQmro40W3+GjLI7nP5m6eN8bkxltFoh578GUHGrbauptcbtFuV5DHVt8/Y/Gecy4Mfjk8xlwY8nlOCODzkc6P42nhHvwzMzu3ha4dSSkzNlOuFkZZWeidzwrz0kuabmZsrKysrLX9fWNt/AHkP2N8bYtW+NST1W8Z8jiTl5BJH2mXL24028PL08bLqyXURERFjH9btdrv+N43+wRDHBFu6eCIi3aiIOBiPqIOCIjyERERH9js/idz5Hf7J5jzkcPL/xfZ/FuPI/saJ67fOJ8w/MMFj9xlasfsiPuIPmx+4fngLE+bF+Yg+bH7h+bf/CduO/4yP2vnnQyr3s195C6cbLq97drw9z1neHGf8jLhJZffBkEY9rLL5ssXuxng2f3ZHzZZPvIH6pHmxPdvD+7w35h9uMD3bw/uH24w+7B+eMSw+7Gw+7w7B8nhnzeH92L7PGJ7th92H3Yfdh9/jDF43+0RH4AnL2sjs2rZCMi2stNi4+8Ni47ult+AXqssbed6GFbDLGMMu1lOXiWGdhhNgY97FzsYD9vox4bIZyunGRm6wtEmTOwurGcWWQkZkuuA3GMs8GeM4+Rzu34umXJ/bfLvza7xllavi0T9Tll7SYy/E9HtJkW/ALeYSYkmd6GRe04mp8XI7cJnvU+FPi2sNymtSZbkur9QLbZDb8iDKww/F0wYt1M3qC9P/y9bayIh49JeqzzLLD3nHM7x0y5Nln7WZOLNn4mPazx4cstWsPxGGG7qeNcD+vvhmdWU+XJbLVlubIytlu0wHtd/aw6fa79iXHUme9Q4+16t6tE5TBBGdlI9yMcdanLhLp/U3ZYs/MPkMsWR9rLFkS2W9w2OOG7XiF1Yf8Ay9bM4y8ekvXCQYXedW2xSx6YFu5ekg2W27jGJ+LslvzER+sREHmIiD+YQk4z1W8eTEsctxJlJbtXVjazLeFvNuonEtPHpL1xgRmW8gkLWUYEON1LbS6MC6srvY4YkZ/hMC6s3ya8xH6R/aSZytPkysxsmybILJysmQ9rIysgslZt4yZTPSWXVZlmzsWHGdtljZ2WTIT06smys7Ltdjz6N8bee34d/wB84I8++N8FryGUPARG4xhIWCIxtkMEJCxEYnBlEQQF1RwRj+DpwZyX/lyIiI8hEEMW+CIjgiIiPIWP1HBERHn0cbeN2vIeR41/MZ4eHhn97XGyRm72i7xHBw74G7RwbiIYiIiGI8+sZyy/GR/yjuRvTbeEymZJeHcsjMjeiVtYzLMnDMyzdJOXe7eXpLeznba/53c2jgheEe8RKz5G9Opmd8FomeHgtuoMfLotS5PJ++ckRH8MjykW5/iFrym92vL043U+ROBj9tksp8jM8n3H3H3DERY/dj92P3Y/dj92P3Y/cfcfcfcfcfcfcfcR5GZmZmZmbf8AR1xt82uCPx7f0WSZmZmZmZONzMzMzMzMzMzM8MzP4dR/Q0S5fhZ5IiI5f0ixsYj+EzPBFjE2TZfztDxv9XufpMzP8AiOWZlnyERHJERERERERHB+ucOSzwzMzMzPLMzMzNrX67Mz+6zMz53hnhmeGZmZmZmeGfwPlZ8j5G3EREREREREREREREH6pERH5mZ4ZmZmfMRERH/7Mf/EACgRAAMAAgICAgICAgMBAAAAAAABEQIQEiAwUCExQEEDE0JgMlFwkP/aAAgBAgEBPwD/AODKVOJxIPERCEJqEITUJ7LHdILb97Xqv/wSPxzc2lRonr0qQyU8VEqNCY9YmRfX4lMkYigxKs+ERDREOCRiOCSIRChn+iCPgiJ8khB+oXTFGRiZJmJ/kMjEY/8AIyMT9jMUzI/QjIQvsbKZfjQn4CHkViyPinIqKckckNiyG0JifyNiY2LI5DZRMbEylRV6lIandIa6Twz1zeo+qG+iffifTG9R7j9PjpwSSPhjUYkhzWJkJKHwNCJ87h8JDa0xmKPgaRjt+nX2MxpkL6HrEy/Wl9jEL7GU/Y9/sYhp3SMhfRl9+mulkckNl2hsumxfWqhtFFkNo5abEzkh5CY2Jj9mh/7uysrKysrKysrKysrKysrKysrKxewy1EMS00Jaa8S9hlrEyF9H72vseoiIiGhLTWl7DLWJkYkH8H2hIy2hjER0el7DLVh965FbKct0pSi09L2GXnrLtexhEREREQiIiEIREIREIT/WYyPpxIQhCahCan4EZGQ/xI/zk0VFQ9IpR6pe1H5Psgvrp+hD/NhCEJpIZ89US6Yrp+KiGUrKUvoKUpd5Cm8kj6QoxFWqh6qIP18WohDyG6JopUPIqYmXVKhl1S+zfWfG57rEy1Bpa/QkhogkNCXWE7ynFkJTiQSGmcSCQ0cTicWcWcWQhx1xIQWI/wAFDPgbHr9H62npdbp9b8C1kzHq75P31fkvmvnqE0ijjFEU5FQ2cilKcilKUpSrVRSl/AgzIrKysrOTKylOTMfNNR/iT8Kl1kYi3DicTiMx8aXSIREJIiIcURERCEQ0oIhEQaQkQmoP8PIRSl1S6Zj412Yhl7sXRmPV98UPuiIemcWRkZGRkZGfJGY+JFW6UpTkUpyKU5HI5HIpyZyKUpyKU5F7Ihl40NKa4nEeKJ5myv0OK1l40fZ9M5HIo/OsU/QJby8a+SNajI9x+CdIP0KW8vGhD7fHVafRDSY1O0faP8PFdH5qysrKysrKysrK9VlfTJxCyY23tCPhn/YkcUcSLpxIQg0QhDiQhCD+unOH9jOeRzyLfGukWoiDRERDItPpiZY1DwYsXtC2un76fe6J9GXb03Cvrj5PnVKUrORSlKUpeiW34uXVMb/Dx8a0xJEW4iERCHEaRCIYlqlH+Zl0xVP6x/xiU8lKUTGylKXVOWqXVKysr/NfTFwX8hzQ/IluMj6R9I/wI+8flyXdeRDMTIQ18kGioaPocYmN+ObQ9tam/hiRdJrTfXFGSqGmu2PheltNDZyG0ch5UTQ8hMbQmhteNMyWlqaeqMgvgo1pDROqKkRZD/jODI94+kpdWHI5FORSlOQ3rkUpyG+mK1mzHJoWaZ8DSMpdL081CEIQmoQhCE6LWTi6LNnN7Xp09UpSlKUpSlKUe8Vr+R+Be4S28Ex/xtEfZe4S68Uf1o/rP6z+sWCH7dHI5HI5HI5HI5HI5HIf/k//xAAmEQADAAIBBAIBBQEAAAAAAAAAARECEhAgMDFQIUBgAyIycJCA/9oACAEDAQE/AP8ABqlKXm9d9q/+D1+KL2q7D7K/wL+CoqKj4PgqKvZZGzNmbM2ZWbM2ZcjZmzNmbM2ZszZmzNmbMXj2GfjjFJmahjjSIyxMcT4M8eyjHx7DPxx+mZmA26Lxxf3GX8eMUoREVMkoY4nwZJTjHx7DPxx+mZmDHiP4QnTX5M3wvBj5Mx/xMfBDLxxj49hn44Tg3ROG48qJw3G7xsbDdNjFHyZvjHx7DLwRkfVHxGRkfEYqjZwdYkLx7HVGqNUao1RqjVGqNUREREaoiIiIiIvx6/gC/BL/AERP6fpeKXilLzSlKUvF4pSl9ah+o+D4Pg+Oj4+tOZ6LIuRWXIuRszZmzNmbMx9zl4MBEvE+TU1NR/Bh9S919K+nl4E4U2NimxtxkYe5yVRoas1ZqzVmrNWTI1Zj26uYQhCEIQhCEIQhCEIQhCE+vS/QyYvYwnffCS9A/QvhfgT7t+m/RMvQ+n5L27xew8kjc3ZszZmLvbf02qQS+xOnLLqw9VOmd3J9eHvM30JU0NDFfTnqcuhOGxsvU3tXtZ9ePef3IInMJxOITqY1RqdWHfhCE6JxO5Bd283sRMeJqyc4eknMITidE5nEJ15MWQnxEPjD094pSlKXilKUpepudGxtzh6mEITicziE68n2MfcPlqjxfXj2J7WI1NTU1Ihe5hCEIQhCE/qj/9k=)
موارد مصرف آزاسیتیدین:
- سندرم های میلو دیسپلاستیک: (MDS) شامل آنمی مقاوم (RA)، آنمی مقاوم همراه با سیدروبلاست (RARS) در صورتیکه انتقال خون نیاز بوده یا همراه با نوتروپنی یا ترومبوسیتوپنی باشد، آنمی مقاوم همراه با تعداد زیاد بلاست (RAEB) و لوسمی مزمن میلومونوسیتیک (CMMoL)
-موارد مصرف off-labal: لوکمی حاد میلوژنیک (AML)
مکانیسم اثر آزاسیتیدین:
- اثر ضد سرطانی خود را از طریق مهار DNA متیل ترانسفراز اعمال کرده در نتیجه باعث کاهش متیلاسیون DNA می شود. هم چنین اثرات مستقیم سمی روی سلول های خونی غیر طبیعی در مغز استخوان دارد.
فارماکوکینتیک آزاسیتیدین:
- زیست دست یابی: پس از تزریق زیرجلدی به سرعت جذب می شود و پیک غلظت پلاسمایی طی نیم ساعت بدست می آید. طی تزریق وریدی زیست دست یابی ۸۹ % ایجاد می شود.
- متابولیسم: مطالعات برون تن نشان داده است که آزاسیتیدین توسط کبد متابولیزه می شود.
- آزاسیتیدین و متابولیت های آن بطور عمده در ادرار دفع می شود.
- نیمه عمر: ۴ ساعت
عوارض جانبی آزاسیتیدین:
- تهوع، استفراغ، آنمی، ترومبوسیتوپنی، تب، لوکوپنی، اسهال، خستگی، قرمزی محل تزریق، یبوست، نوتروپنی، کبودی پوست
تداخلات دارویی آزاسیتیدین:
- هنوز مشخص نیست که این دارو ایزوآنزیم های سیتوکروم را مهار می کند یا نه. هنوز مطالعات ی مبنی بر تداخل این دارو با داروهای دیگر انجام نشده است.
هشدار های آزاسیتیدین:
موارد منع مصرف:
-حساسیت شدید به این دارو یا مانیتول.
-تومورهای شدید و بدخیم کبدی.
هشدارها:
-آسیب به جنین و تراتوژنیسیتی این دارو در حیوانات دیده شده است. لذا حین درمان از بارداری جلوگیری گردد. مردان نیز در حین استفاده از این دارو نبایستی پدر شوند.
-آسیب های کبدی و کلیوی گزارش شده است.
توصیه های دارویی آزاسیتیدین:
- زنان و مردان تحت درمان بایستی از بروز بارداری جلوگیری کنند.
- از شیردهی خودداری گردد.