اپیروبیسین
Epirubicin
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ny6jMqPVsA69gxWhPO2W6YrllPGgD17AOncMLoZ86W0S755TxwusD2aIo6dwyasZ86AL0xlPHE6XmPbSBd+gCxE85ANbxlPEjpeZfYWEx0vp0AczlSkt3nnlPHk2yX2ccmU36LvvQ5WReVrWmc3UxlPHkLV9jMy1w13rXaAJeLottM5zmOflh0U9UUnn12ou6IXm10sMysSGOWRT08Zl05zp2lOOLvC1ve83osgxkOeLGp01y4lmt9aCBRrfHjuS479ucACVxnNtNdwAAqAAAIvJYuO1AAAAAAEAKAAAAAACAFAAAAAAARQAAAAAAAAP//EABkBAQEBAQEBAAAAAAAAAAAAAAABAgMEBf/aAAgBAxAAAACSwIDQAAAAAAAMzYAAAAAEIATVAAAAABYlBUAAAAAAgACgAAAAAzQIDQAAAAAMgANAAAAAABKEjQziXegAAABQAY0Y+dC+/qF0FGcgBQAYtZ8fJdevqF650G/bPlABQAmNgiga9l7LMau/lYAJAAy6AAC3WtA45AMrc5NLMugABr6AWl8HEAyABNgAG/fzS660+fxAMhIA6SgFRr2ANdvnc26xkzkADWgBd81AHu8vL394nn8kzkADWgA3hQB7vLz9foJw8bOQANaACpr0KDp3+dyq2RM5AA3QA1Jr2cO264O2/BgEJgADdlQDcmvdmzpS352AQmAANiEU6Sa+lQo+bgQM5AA3QhZOkmvpWueew+bgEJgAF2AE3Jr6dPNPUPlwAnMAF2AE3m6+lTyz1k+YRZe3LGIAal0gCOmbfp04uxPmenZpvl45OYNA0lyKjpm36OwZj503rTPpx5c2YoA0yELdRe3vHKS3wXIvsz5YhIKKkShaV077A8Xe9HHtrj54LpnREzKyFloq6lDHf0pLnl5wIFgzuhcS0AB6b2nNrn5gAQBUCgAqdnMd+GQAIAAoAFlkqUAAIAFAAAAAAEAFAAAAAABCgAAAA//EADcQAAICAQIFAQgBBAICAgMBAAECAAMEERIFExQhMRAVICIwMjM0QUAjQlFgJFA1QyVSU2Ficf/aAAgBAQABCAD01Wdv4/aaiDv4/wBHvJWv0xVrfmB+mpK7hZTTWQGTGO873prr3cwYiNWrqcUcxhKsVzo1hxAFck44NYZGxNKzpfS9e1lGPkkAjp8r4pYttTFW3NNzTc03NNWmrTVpqZqZrOCDW+6OAHYD/RsBA+T3NFB88RupxbUREFLqhOW/DsRlR734dQKy+Z0GMlTB/Z1OPRZZVj4VyI4ofhuQ/IWj2ZkXclEsw2yuQoPDDeaJacFMrp5avC6reQeTg83lG3oUy+nF/svHv5BubhtFvLfoMKHh2DG4VgtH4HQfoy8R8SzY/rwP7t0f62/0fh70obmfqMeG1DziTdX8AF9WLc7M6tQSgY21vt38yh9odL9qoCDUCxgetPiQmgO21WqV1YI9RdWexqWsQxbKhsaLdWdHY21NozW2VMAwOUPj0bLQB9DxHFRjus41jL9GZlvl2729eCfdtj/U3+j3Hda/pgJUtIL2virUVXD9nDG1CnCGL/yqPZ/SnlFsEYY6iqqt0tdnxKF5gF2ClVdjijFSylrGGHQWcFqKEqZ5j2pW/wAWe+B0binhT4I39RTbiBrzfi28MGRkE1XYitcbrentyzs5GHqIaMblMVPn3OCfXdG+o/6PYro7B0fY6sWzNUtULk7ECQZiBGBqyVrq2Tre6kVXmvUzqyQwL3bqlrHvLXYw1AqsPgVWkajk3aawVWE6DEXlXjm1rXyrEsFWjlXFCEkA46MGIIKnQ8EH5EPn/RqU321rMvBx8v68jg2TXqa3ptrOj6zUzX3LcSusCHCbUCVULZfyj0nw7pZiIm+NhBApi4QL7DQ9lOyparLBWdCbeVtF+RdQibK7CTVr1DhFtW++yj461vDclzztzo5pfahSq0hrGI4H9GZD5P8Ao2BXraW9WQONGt4XhW+X4BR/Y/AcgfQ3B89fD4OWndiCNQduNopmzH2awJjA99uLCuMAdLBUN2xRj7E12UcssWXD17aYmh024mqz/ifFHFOo2N0e3RSmEAY3Sanbuxdj6Tg32MyHyf8ARl4j0XaDj9X79v409v409vY09vY09u4kHHMSe3MOX5/CskaWXVYu48nlrNghAE0m2bZpNBNJoJoJpNJoJoJ29OE6DCyTD5P+jZ31L6dNbykti8PyX3yvCvsd0D0WpbymbAyUetCMDJNjJFwclw5BotFPNNGLdkbtgwslq3cWYl9dQtajGuvDFOmu5dlnzuFjTAujeT/o2d5X0xLahh49Vt1bXrkrXdplDJpptqdcpaw620WY9dToHW2pNpa7KyKxaXwrFtxKqHd3orfciWNs2YdnOxdjbxj8wHEz6h83hv4Dw+f9Gz/KelGILce+49AvIBXLw66K99aYOW6q46R1qyWsxaeovSuW4VSWVonRZOw2QYWSFVmtwLhZetWJQMh3RhiO9FD1jCyTYa5j44syDTZXhoalZxh37VdsmoUX2Vj5PDvwDD5/0bP8p6YtyVJkhuuoFCkZuVRbTsqGbTsRZ1WJYtiOhxaslTGzsdWoEGdT2lhXk33kcQxtbZRnrzUNgysSg41dXW4nMsEtyNcw3rbn0NlVupy8QY+xcy1Lsm2xPk8O/Bh8/wCjZ/8AZ8ou5G0/weG/hGHz/o2cjvsC9NkTpr50+ROlyZ0mTOlyJ0uROlyJ0uTOlyZ0uTOlyJ0uROlyJ0uROlyJ0uTOkyZ0mTOkyp0mVDi5I8sjr9XucO/Ch8n00/0Sr8un0tyKKCBb1+HK7UtXdX6dZjbinu2ZFNJ0sV1dQys6opZqsim4kVej5eNW5R9QfHq1dbg7sjg9FgJqvxrcd9lsE4d+F8nX0+D9/wBKa1/rUTX/ALiv8mn0499dEw+Fpk0JaUWvhmGxPtrG2EzC4jVluUFnQ9W2uXxKrFu5bpxOi29KUo4rRfctQt4rRTe9J4596oyni1OPj49UsvoycC6ycI6XmW8jI4tRQ5QYvE6cl9k4j0YzbeZlZ9WItIZ+N0KBtxcpMqrmJ65ONXk1lHuqemxq2nDvw4fPvN2E1m6d/f3kQMG/7VfyKPTjvnHmLw3JyKRamTS9HCHrfg1Vdj37+HHZxGqX9s6ycb/NmFg41VNVo4f+fTM/txG6cb+7RLqKhwiiwYBPs/iAnBjocmcMAfPqLvw6jqjcOL/+RunGfpw5dVWOE0OOB/Yu93jiaXVWenDvw/fvbQqICGE09dJpNJp6Ea9go26fNd1rALdTXNxnMEFysCQXMNoGuos10hs0BJ3+J1NY89TVOprnU1zqap1NU6mqdRVOoqnPqiOr/T/DH38f04zTbbyNlL8Ux0CVu+VbwzKORg25VJtfH4ViWnLW18jGvOZYw4xRdZlBkxgRj1KeTlYuVuW+jMsyTZZxim2x6ClvXDFqx3xMSyvhuTu4PRatlofkZOBl8xaaMnMzec/FaLrM6xk4tTbYmJstotPCaUHBqrKqrg/ucc8Y/pw78P376t4BALLFtgdYCkC1mcuucuuFa58M3Tux+bykutRG9nY0vurx8haIq0JXa7PdgmlHNllK5FdBqbHsstRBZiObULZGOMbnIbsQipWR6DkNQeZh3I0dMRMmumbcAvagx8fCyU3oeHY36bhaf234tmOfi9MZtH0/if8Avx/TXuJr/jLpbIxra14dgW4djs/pr6a+uvrrNZrNfQkDufc44fx/Thv4Z99vBiqG0BOLr4OPYJy3E0afFPigVjBU8Ne0amvuCfmrYld6M3WY0NyPvKu6MHFlXLUDY2Qit36qntp1NU6mn99TX+ky6Q2rdRUXJHNaLeNZzlUknrKtJ7RqXWZOU2QRr6VHR1P8Q/ex/TJt5WditKr7N/ELEOZ8b6Bsh78A205dzrda1V93MpW2rJybNlqpdkUJlupfZmO5rybt+Pzasi++u5yuRbswkppyHoxr3bGyTa9qNcdOIYoi515RLSbxVdnsaMt2tVLKbsuzlOa3uXGzmsNt7OtdPW2umGa8W6yznLbOKZAvyTtnC/w3g8D3j4Mr8xIY8MAggjRx2lQ0X5uaQoUkEEDTCtKVspe8WUkBrwyVK2azX7doWlt2i1Y+r7ruRzRy3OH32u2JoNpevnBkGdQvcV5iJY7Rs2k1spqNQ379aGB0u5LHUeg8xDqqn+G/3Mf0ektk0XAUiu7LtfAo34+TvTHyt+LzKMUpTfU1VF5soNtWPk1balOI5py0hxy1xc141+7GW2jHeui6s9NfWMNq+itai1GoS0F2ssoZ8qi4DCsGMlUVEyr+JAUU3bhzaKcqs1Ielu2Zdceq9HV6RhFBhgU1chsh2z+Kag1Y/pwz8N4PHv8ALAJIUf4OsYH00gBgUwr/AJZR4mnzb6Vu21tk4GXgklVzGHlcmowW7gJq3oN58e5WiuwB6VO+nIr1UTpk/VdOxmAdQ6CcsAgFqw1Zf0o70p/DyrRSKrD7axZ7axJ7ZxJ7ZxJ7ZxJ7ZxJ7ZxJ7ZxJ7ZxJ7ZxZ7ZxJ7ZxJ7ZxJ7ZxJ7ZxJ7ZxJ7ZxIOMYY8e2cWe2sWe2sWHjWNLONt/wCq/Nyb/uevDPw3g8fILMARK2Y6a6Wfoi8QdRNL/wBs23ylutgWP5+c/wBST9S7huHf3a/gDeabeG51Hc77FJEGRcJjZWVqwrTJzNCAl+UN86vI07tnOgAbq7R8MGVfOpv7TqbtzPGzrR2LX3i4NOqyY2ZYqMzjKrPnBdbKTt/hcS/HH8zhf4bweB8hl3kKKB2Zodug1KLrOUmkSqsaRlGg237qb94Dq6Kw+bpqy+7Zj0XfcfguA/h+AJ/6b+EZ9IJDG1CQ294ST5FlikEcx9SZzHnMsm9yRqt1q+DY587jpp6cIt0ter+HxH8aHzMXHOTelQ9m8PrKI+fw5cYI9ScMxKKQ9+bwupKTdRh8LqakW3vwvEup5mMQQSD72PiX5O7lWcMopxHY49DX2pWp4dgVFEfPwOmdNicMxKKQ+Rm8MqFXNo93hf4bweB7pIHnVj417gSsKbHBBXQLByxNa5/Smtf61EvpWwExHNG5G6tk81XV2gbfl5VrVIHUZ2UZ12XOuy512VOuyp12VOuyp12VLbnuBFnIpnJqnJqnKqnKrnLrnLrm1JtWfDNFmFoLH0/hcRH/ABWh8ym6yh99eFVk5dleRfn3IbcWicX/AA3ijdhLGH/DM4R+FXMhdL7gNpmh9NJoZpKci6jtXkfFhvODAdSZxH8rBmeoKVa8W/DeIN2GAZtMbGsWhbz6cL/DeD3C/wCl19PHha20nKaCpoV7TbNJowm4iW6OCC1B1O0l0Mxs/X4LR37j5Od9mJ4i02EKQ2PaoUx6bKyu7prddJ09uiw1WKGJWmx13DprtSIlVjhirVOgUt8nD+4/8PiH4rQ+Zg0DIya6zYlnK20ZGDdiaZL5dRzMRhVa3TYPx4zjJw124FL4mIFtwyLOJIZzrOTvhQoc/kcUG3LMIJsRJUtaVUKuZYa8TGRBLgeiacNuFOUhOZiWX3YrpxS8VilZl1HMxCKrmGNh6Pwr77yq2xugJtpsswQtToyMVbScKtXlvT7jvr2G1tIBNSToAEWbgYDAfQ+h8R4xhH+CA+oa2krrtxc01kJYCrAEfIz/ALUXxKsita1RufUhLCzl6qF51QbRTdS23V7l0tBrtpRO3Oq36yuynRzL7EdE0/8A9+RhD4rP4fEPxLJ+zK3sRga+ry4+RfYu168nIqGiWXXW/crutqJNdmVkWjR1ZkYMvMu02ynLNZsNmRe2RaXa/Ptu2gLfciFFZ3YKrQ5N5Xb6Ll5KjQMzOSWTIvrGiWW22/cV3QkqLbBt0W+9OysWYktOF/kmD0ssJO1VUKBGaAF54GgMAmsV+03QtNTrC3aNGBmvpsDqZdTp3GFk8ptjfIzx/QieDK9eQCbdjXoXVaNylaUau8BmWosxZaajrtdaHV2NYQisqKcfWvWrlc6xCvKtILZATVNvv4Xmz+Hn/iW+mABzbWl3PHDk5qY+KKEZlwsbmETGordsvXocUJZMmulLKK06XEZtgy6rf+NauaoXKt0/gcL/ACvS+zaCoqHYtDB8R0HYDQH0HiETxNTNfXSbY9c8RDHQGXVbCZg5G8bH9/P+zF8TT3NILLFUqPc0mnyML+/+HnfiXelVrUuHU22MNp5j6ASnMtp3aV5FlfN282z4pqSQTzLILrRoI7tY7O38Dhf5QjEKhMKs77Z8KicxmfRVXYoEMPoDO00E0E0mk0hWaQiNWCIFAn6MsQOsCsjnbRaLqlce9lIrooIwMfSdBROgonQ486CidDjzocedDjzoaJ0OPOhonRY86LHnR406LHnR48bAoPi3CsQEr6YI7P7p7TmLOZOYJzFnME5qwOh9/M/Fu/l/qcL/AC1lrAsFijRZfaF0WYtfY2EzSaTbNs09zT00mkKzbGWeJoQYy7WVhhPyrmrPvZHhIsv5lme9cxaDim1z7Xx9hIycmm/B5gqzKsbEpY+1KCtjD2jV0/PnE8g2VY1iUcUpVaa2ymr6+pZk8Rrot5YGZTlY1xmHkVUYdtqnjFe0MKrFtqSxfTOxwBzFMwPps9yywIBCxPnX3wSIt3gN+vcyx/xrv5Z8ThzbcpTK9WYsWcKCSut1yiABQAPXSaTSEe8R6aQiFYVjL2likautT8ytH97J+hYkyFQ57iyirCrTIGPgvUKcxbK//G2y7/x2JMmlF4b8AtT2YUmV/wCOxNcpq3pwgmVr7RxpUypxa3eluK4zUpp/8VfNB7LmB+HR65ABpt1mD9D+5e452kHf3NPd8yknx7mV+Nd/L7zAVOTaYgl5JfaMOnTc59NJp6ntqYXm4wNNZrNZr66QiMIRHHciYvZCvvZPhIniWcPxbXZ2GDTQlppwuGh636k4eOaeTGwMV0RC1SNVyiOF4QBEfCxnrRGHDsQWBw+JRZaLmvwsa999iYtFdbIow8cVNUOjxjWKoiLWoRfTI7UW+mB9D+5lVMHLhWIgaaiaCbJy5yyJtmg9KfqPuZP490/Q+Wqs7BV6S2dHZOkt/ToyMVb5fDx2YzwCSSzNKl2VqPft8eoHv7/871PppHX4xKmHMOnu5P0LE8RrbeUwhynFj1nnXB1sZrrxpBkWO3wVXW6BGryLeTVt59j87S261kIRcix7iFusZL9VN9uxt/UWm7aguusR2Fd1iVhibrgTXMZ3dbA+deNpqWYH239zI+00U/5CE+NjCd5qZr6d5oYKzFUKBp65H2Lp+vl0HS1PcyTrc/zMBdKRLvtNKF3XKPkW/oeo98wzVotn+bCWBKogr2e9kkAJqjpthqoKFCta8621looAIDVUvt1NVBIY8qj4ZycfRRNtOjiNTjMdSK6A++OKHOrW11OpC6Y28PFXFUkgDFUEA24dQ0FmZ2Zam7kkzAA5be5kg8kxfMr9CqzlrOWIEWBVmg97I+xd8wEiVMz1qzSzVUYgknufl4Q/opLuwAmIh5hb5Fvkegg94xvT9+g7Q2Ku1F93iH4zSsfDNPQfJCk+NNPO0wgj3cD6G9zz5fHUEkKjCD3B6aQL392/7Ns/Xy6qmtOgUbVCiMAwKy2lqz8zEH9FJd3cCYq6KCSPftHg+g9wQzWaw+43iMwpR2I8D3eI/jtF8CVBVx0aZLHl6HbXjUbplVq9G/3x5AJuqrRVpy0UohLll2hMxnLqGnkgRkZDo0wPoPu2nQCIz81gFW3SHmjzzf8AItQxWJ8AE+T59637Vny66zY4UIioABp6socEG6o1Pp8o+Ji/ZrhUFiZR9HoRNPdt+n3hD6kTbD2mvgy/MRAdtdr3WHev0r7vEPxnifSIHyEoBUnfi6vf8WK0t7Yfeiuo173sx6dlu049IJSY1YsuVW5FLhStlFOq6ZIqR9iYtArQO2RZbY6yxspTXu4hp/TlNdXLpJaurZbtzvvwzA+hvcPbubbCdTEXUnUQssLmc2BgZr3jn3rPtv8ALwvLn3sz6EPyjMUHk1RP7pQ3xMJn55x2FddfFrx9dfFcZ/K30WfR62nxNRAfcEM0gSM1afU+dQvaXcQ//G99th+JvolVWyxVI8L7vEfxnifSsqyra02m7LaxdoqzHrTYb8p7hpFuKoFBynIthvrCnXFsSu0Mz5THbtbKYlSHfe5c9dbLcqy1dpXOtUaG257mDMuRYoQDqLNGEsyrLAQZgfbPq9gWFncgQlAe1S/3ncs7T4ZophrH6+JZfbbUWIoy1O3X3H+h5/n5WF5efr109Mz6F+UfEx/sVRfpMoP9QziB1y7o2PTsDs2Ind4lNjo7r/y6tIM/LXwOLZI8ni1jkajii/v2rV+xxWme1KJ7UqntQfo8TtPjr8k9g9uXoC5JPmP5ldbWOEW1CmqFO926DwPdz/xnlf0rGcBbIj0BFBuRAtWhOOCwO+nmgxnqZXVbv/X83A+g+hbsdGdATobDoBFAYwbtBB7ms11jqGEFPJeV7k9xvpaHy3ysLy/vZn21+U3gzHP9Cqf2mUE7xM38q6JkWp46oPuF1L0LXbuW5GYS/tjOzX0o2Q7AY2M1j7zi1vQ3K6WkYoY5VKU2ha9JpNPTHJF9Oltd+mUr1Y73btq4yVq3MyVVbWVcfTn1a5X3bd1WjEEe7xD8Z4n0L/EwPtmX2hQVDWHaAGYgERVLkAKmwATSaTT0KzSaQiMNPIvKaK63Lr29CexjfU3ysL6n90zM+2PlHwZj/Yrh+mVfWsyOHC52dbcDKr1MII8+mp0Igd1YOOrv3locq4oEhybDUajZY1hBb3KWVLqnYXCnnWxb3QMtfPt1BlhJOpxQpyag2UAbnnizt7vEPxnlf0L/ABMR9lLNGJJJMJJmPWQAze5qBNwPqY4JEb/9uWrJ0wckXLs9DZ2jfU3ysL6n97M+2PlHxMc60VCHxE7FYIOLFHKvU9eRUrx8DEfy3CKD9J4Q/wCm4TkjweG5gnQZSw4mSPPTXidLkzo8qDh+WYOFZR8jg9v79jjTvZwe0DVHRkYqzyqmyu2hjdqXYkEc4D3uIfjvE+kfJrqrKgzk1ywAOwHyEYhFE17elCb7R7ztqxgaCwibgfQy1I4BBBrPIvR1B1AM58PlvlYX1v72Z9sfJMPiY/2a457T9LF/UqyORbcTkZnIpxnqo4iLb1qZT/8AIkRbqHLBVKsAR3lnEUryenPcRuIVpk9P6EkAmYud1NrJPHcgggEenEcVbqS8abh1OGpt+62o7Wr73EPxnifSvycfds7nxG11OvyE7AejTF7d/dPg+g9NZvm8Q95dV+1ddwmM26lZvafs/Kwvreae7mfa+UZjn+kk1n9oieFiPfhW2ls+5bqMOxb2D5uHsTvxh5j4/U5dqS9eRmU1jKtsXie1cze3E9EqvycfiHKt59p4psluRlZGa1FWIc2u62u7AutdsrdQll+PkMeDHWi31t+3ZCdHUy0W9VjGWhuYwZABcp97iX47RfpHyKat5JPpbWGBb5I8D1o8RfHuP2VvQe4YrkeexEerRtZij+n6fv5VFvKcmLk0GC6owWVzm1xsiqZF62KFX5VB+FYsP0iL9IiWpYF04ljWWinlVcOx67VuCYLrmNkTEwb6MprW4jTd1YtWwX256Wvlb14mXCE5XExYun/zM3DE4o9luJkZWTbkMeHI+mZMKi5cbLQ8Lx7aKrOb6W/bfVhqwWEFczFEvH9VopJdJrNZrNZrOIfYaL4HyMf6W9X+lvlmUfRE7qPctOiH0HuGazTvPPmpQoI9P2f5RlPhYnkT9qIPplSWJtMGTa4XZTk9kV0yanVjDkV/BpzFV0X0JVSNfgUzavmNsYgN8KrAQQCPMW5H+nnVbmWVZCWuypxK7lYxEP1LLLq1yqC9h1Y6IGD9zZOZOaJzROaJm2a1EQePkY/0H1f6W+R+xB3hUgiWbdsoTSkxB8PuX/RPimp9BBCJsmhmqp3NJ3An0/Z/iuuNWmMzZlC497IvuVeFieTK/isntJEdkcX0XIRX0g5NSAYvw2LGpudWdn22vSQvwGrarFApWvei4plTOzYlrYtl7vU7XttyVID3L3LvYxAgKG+3mog12gV2MoSIvTlrrcvKOTbvLfUIfhy8bSzvYYCNY18bJhyp1U6uNcLO0XwPkY/0er/S3yVP7jHWN4EpvoCqsRlPiael4+CaQK02wLAIY1ta+WyPO1WJPej6PR1KsQ38RnqSrBNudTywGKUKy1k9MiMCr0oxtcRe2yJ3MxlPMl/3rYuJkNWLVTIvqPaviuQPqTjFf9ycUxTBm4b+FbF07A1fDolVCtqqVUoxZWStiS1lVbVsi/8AGRUDNlYYIJbiWGss4xX/AOu/ItvYmyD61lm85dK1v2eags2jx4fWuDx8jH+g+r/Q3yV+gTad0vsITSVUO6BxstTSLkXoewzb519n7bO3jSdUJ1Kzq/8AHV2fo5FphZj5iIX1gr0AlH0emV94/wAVLS7Vi18m5983uBoOY8NmqbfSpC4SBCJjD9zI+9dMTIvvNCAY9T517m+qjIw7Lq14ZVyle3KxXxbAp9dZqZqY9N1QVnpx7cgkV34l2PobKeF2WIrvk47Y9pRvRCq2IzKedkqyabrVAOkaND64yK+/UeB8gMy+OdZOdZC7t5+QoB5YnfdpLKbLddiG2nsedqVLdQh8uaXInKoJGiUVEd3AV2A9GrUodFpdgDLE2ECGlxrKvBgAlP0emem3pn+f7Op3rWOipWlHs6SgUV2smDQVo1HDydgj4+KQeVfh0VHbHwKd1iLVhizGe08nE6fnS3EqqQGGU1qESbZQumkv+9dKa3rxFGPgLajZKXYpHQXzP+3izjGmyj3sG6itgtnGfs0xNaOFbkuXfgUhs06XYInGBrdTPZt+0lstFru2qgBdAR2zkRT3tCxTpqgeND643au8xTqqn56LXtr3OArMPQ6jyPIiE7hB9UoQrvMtzCmQ1MOPTYAT0mOzFV9nn9dBb+uiyJ0d86K+DBv/AGMW7bLMS9BqP2NbH+8DUQEOqyr6B6ZFHP4amnzvaFRsCEX1HHpRXyyuNTXVXnpUuKsTLppWoDn4tNDVrlX1WlnFmfXY96MM6mvk1q1tfTGpb8jHsVfSn7VUUd5UO8u+9bGrvoAcJmXJcLpdxFraTUqZuLfXSt/EctMh0FRsX49FooZyBhoj236jGxgzub6canHtcYo/5FInGvoplQ6rhorrzrVx8WquWWYt/T2nLy1uy1cPnjvtyMprwAw+pZytuYlkT76zRVOkeND6aSj7OTMSzVdnz630FYDtWXDDmVaSxkKkxD8SxfrgBLgxRopl+i5zNZexFuW8OVahyrB1eSgo35GY70ZISjO5hFJozQuMrvfm7qQwt4iazaops5tSP6ZaAXrpZ2W+V/QIolX0D0w++PVM7GOPkMPeXEoGLTZOgvNXMF2JZRWrvbgE8rkjh1m2/eeHZAKg2Yd9QcsMDI1fRMDJdAwXCyGq5g6S7UCW4d9Ve9hSvS82W4Dc0rUmHc+7TFo51jB2oovq34y4TpbULGxH5gCmV/bri+ZUJd962WX1NoAelvPYYitdcgbAtUd68W6xN6NQ6msGvKuxt1Yqvekuyi60OXjWOw0YMykEPbY/1qzL9OpJ1PuAauojG3rDyqieeu7+6NGh9cNd/NSIWQgxHDqCPkIjO21els1InTvtLTpbJ077Sx6ewbY2O4KgdO2rhno2oGNfd1ir3MoA7mL9AgvQuUZMTHa+1nswKnW5RkYj28lk9nXcvKWV4eTzt7jByUoxtLcbLvRN74FrHK0qRkqRDMwjnrLA2l0qUlOySv6F9MLvjUzOxeqoKggqSD7luVux8etBnUBUc5d63shBzqzWyw5tDi1W6yhsp7D19PUhjRnoEIdc2vdisVzaNqORm42iubcylsVq5RdRyGpuGfTzrXi59PxSjIFV7OwyqKQiULmopM52zBtJlXeqqLKDrrL/AL1sER2RgyjItHMM6m4oENWS1aBA2RTeU3XsHutce+AzeCrDzXS7uUi4A5gjAc7QDcM7uiAUpZNdbDo4jiH14Wo5rGZ1BoybFldjVnUI6uNV9+l+XYGK5KHy1w2BQcpD2PU1/UzZKHYQctNdxbJV9WjXo1SpKvupP2Zjnu0tvWimjVnx717cjV9Ry7VMXmoILrSNIclwQYbm5aPDksBrObY3aLZbtWI5pDNYztbZuNmp5+lZIrGimJ9I9MD8an04pg7wb6v4p9aPsVQTG8NL/u2/Ix6qbKnDHFo5jmUYiXI7G7FCUarj0o+JGxKCSDyMavVCGxK8iwDq6EUpGyXfL59YGYyaMv3UlfbPuMCLZi0JKPr0j19o6R1hHpwv7jziWJ1FQdYrMhBWrIV/NXexIyJbY8tpStGhprby9NWhMbFr1AHTVbVI6eo9x0yR6krvp0NSklX6akb9aN+wcs10Eki6uvZbbKfupP3KPLTO+zjCVqhorleMnLV2a6+l2SLn3jyM9/314/fXiLbY2jhLr3GqXZWSjbCzM5JZddy7WXtcJX8A2yswePTh/wCLTHYIjNDmWd7JlYQvq6rH9QCSAHqsr03zQnwyspG70Wt3126EEg+4QV7GMGUkN6AHQmfoyj7NU/UoP1y3u7/IBIBnNs1JgZgNFFto7TGxnup1i4Z1pM6RbnsNi4lKbWHKWrkKGux1sNrdVWGMrdEtR2pfflXOUpPLxbBjJrYm5q5ZTLKo6EenC/uP6cSwuW3Oq9EtsTwmWwOp6mtvPOUzmiG0azmroBOao8c1YbVPk3DWG5e85yDxzUhtLqFlP3U9KfDTNb4cUSi2hRWzVsLaa9rolt9+pxQPHJPOWoDFcns9L1gM1TsqC61LkKd7qVOUECY9WqkFStwBYfch8MZX3g8enDvxaYQCCJbg2vogpqWitUXM4bXkfGltNlLlbJg6c+JXkPylsbHqJUiuta0IjVINzx6aaua0yEVHtVU39JVyRSbmcWbKrVpWVrXureJTUdink19ObI9SLuaUVb8jSWotz0uwprY1klKgWaNotd4WU/Zqn7WVHvZH+t4fTX10ltFtOm+EEEqfSnLelFResbRNFuuVTt25Z0aNi5AVy1eNUQtZFNCIVlCcy9BNHbLyeWg214QGMm3JrE2xq5ZTrLqI6aGcL+7ZMgPsG3G3veVXO4YaiXplab3VTyq7HC19K2oEbFTVlUYkrrVrEWcpLj/T6VNBocRQBr0nYmXY6puMqxQ9DMej8Q4qjWXKKnAXDs32oDK+ymcQbTpDObU+zdyU+EryXRlCqbUZd4vByBaeqMe3eVJ619AIuXausNrly85jxCTYmpQakzttlfeDxCJw38WqFdZsgX0tpqvXbZkcHde9DJZU3xNbaSpPNt1BnOt1DQXWBgwNjnXUu511SyxNdtV/LFpgscKFDXWsQx51oDAc2yc6wEkb3GuldhQiW5BfbtNjknXe0/RlH2Kov1iKwG+N9TQ+5rFbuJ1aPezHKvpfliqzIxTZqDbjG1RC+DqxhvxFdtBlYgVVluZQ1D1AZiipFFufZYHWdRbsFcDN30xfv1aeLMthzURMffiKXvR/UrHpDCZGIfI4chFtoPxa9tGHiZXC67zvqtx78dvi6m3cGnUW/FOot1nPtJ1m9tytFyXDl2S61ANBfaIb7Y11jBgeZZ8Oj5DsqgF7IxZvOB+Snov0ziI1Skyi3X4DATBa4BERdzqsbHXVQvIIZBDi/wCHoRBqeVj9tazVt0g75I010CmDwWlfkD0ysFk1YcM/GQe+9aWAh7eE0P8AQ/Brx9D4GWnk0XDzybJybZybZybZyrZyrDOTZOVZDVZOVZOXZDW82PNGn6lH2Kog+KBdS0tQpbYhhHogQUIScVtgYLiOVBbkW6KYa3XyuO7Vh4lNjkhVqscqF5VkGPYQYKH5y1McM811C4agAtkVomMgUTGtWm0OzXu++VY9lzaV0U8hAvu6azp9LN9fLtnLtnLtnLtjVOw0L8KqeHgqnx7EE9iCexBPYiz2Ik9iJPYiz2Is9iLDwRYeCrDwZZXw4UPvA8xuyTJG5UBIKkiVZAbs0AJ8CamIRvXduxgQZzaCNTz618GyzUAJue861k61AKAApiHuB6aTpKNxaclJyknKScpJyknJScmucmuciuHHqhxaTOkonR0ToqJ0VE6KidDROgonQ0Q4NE6GiNhUCNiUiNj1iclIKa4nYARE7azaBM3C539St6rEJDQj/C22ICqjLt+HUZZ11K5gXvLLVsUA82lkTe96VlFK5la7TOrr2gQ5wLl51AS1nrqzSv3GutbzqTF8ynEvuOiUcKRSGtVVUAL/ABzGMd5u1M/cf7cv+pZfV23iLbbVprVmom4zrsclCOrxCJ1WHOrw4c7GDAiziVbDQLmlz2o1a4sd6o1WptGgC41bMQx/imGGNGmkFcWuIneDssC6zYNYwQA7nxsbI7K3Bqz9D8GvH0vw3MSNjXr5KsPM1momo9ACYKbW8LhZTROG3H6hwpB5popoPau1G7D+QYxjtG7ypAWiY3ksalQay6vep0I8g245GrKtyDzzaCAC5pI+E8htTCMXWDpBEagb1L3UoSFaws+8K3YEJVY/01YYHdx27D+MYRGEIgWBZoBB2aA9oPEZgoJgBt7sP8CazdNTNe+kKVt9XKpMNVE5dEGz9bkELrCY01YRLPG5/hPap9QAYO5/imNHjKTGG3zU/wDUWPHJKwFRLLKtdCVobxZiUvDgP/b0V86LJnQZUfAykGp6az918ML94vCa/wB010VALP12g/jkQiETbAs8TWdmiGHxNhcgHcqzmrDZC8LQ2trBao0MFwm4NCwGhhtBE1Yw7p8U1abjpFVmInIZkMWDzNdF1lfgn+MRCmsYAR11MXsw0VgygFtO8d2MJHpVdUi6Szc5LAaaxe40UrYsTW0gPdi7ASBuX6Uyj2D7twGq3PWYpDqCFILAD+PpCJpNI0du0r8HT/8ApQSQDNY6K5hrKTaRP1Ae8G3WMV2w6aTv+tGioxiArG7w1trOXFr7yqsDy7gAxQTFT9ksWMHj+PpGXWPXGBG0QdhtK+QC+LqTt6Ufs4c6NgN051oUKHR2YtKtiAFnuY9lVV07vUbCQDjOJyWlVbCBC0LhRsSkdtf5Ok0mkK6y2vsZS+mqxtwJsRbFfuu8/wB2qN40dZqp86D9BJylM5SgwVEk6GkfvlLNgmgEE2zaJ8Iht/8AoKyTqQiqO5cntATY4UfySsupJGoD7hodxBhcmB5ujMGI10r8jRZy628qKhCy/wBvxfrazedta+eYo8MzN5JCaGVKQnf+XpCgMtxjqGUOQe7KjkGB3Xzza/7kYf2FifOimfH+t9ggu/zzljWIZvSc1YbFM3EjsN82OYKRPgSG3xt7nz3c7VrrCAfzLcdX7h0tT6gZ47wWL+2cBSVFjEahrrVnVPBlW/qu612IaxsgfTzLtG5idpugLsdEpxtp3P8AztJZQj+XxnTx8X77GGpDFDj6RZZqNQQZo01YTdPhnwTVRNyzeJzBGuM3sYAfJ7fpanb6lRU8fznoqfycT/6tjWCGpv2FIhWFBOUP1y2gqOsXHcxcW0+UxKx5VVUDT/omRW8tiofBxnHg1WDzpO0BYeNbNIUczltNlk2WTa4m0nzsSCv/AAKrIKV/YVR4/wCk0E2rNiTYk2rNP+sKIZyazDRWJyknLWcpYKkMFFcFaCaD/tv/xAA4EAACAQIDBAkDAwQCAwEAAAABAgADERIhMRAiQVEEEyAwQFJhcZEyU4FQYKEzQnKSFCM0YrHB/9oACAEBAAk/ANhEPhzCJn+yOOw6LcZ2h1w23oW3mysZiwXOhhqDlaM+E6zrCuHI+sFULbW063IkRql772XOdaXXWwmPAQMzAbHjeI2UuDGMYxjGMJhMJhMOzyTmf2OAQqEyjT+J0Oi1xxWdFoi/pOiAkidEFnFxYzoqnGJ0b+oNBOiNhPEmUmGXEyg18+JnQxbFa4Yyg4bFznRQd4LqZQYtOjG/+c6KpOIC86Ldp0OUElBZSlR1hB7HknM/seoqnJczK9P/AGEq9GP27kQ9HYld44hkZ1BOHdOOHo9ggucQ1n/HO8dWGkNCwJtvDSNR+uxGIZLB0e+I2sRpB0cNitqNDP8Aj5LrcZtOoG6Sd4azqAdScQ1hoEZ4iSIaANzi3hB0cNiOrC9oejlsWuIR+jl8WpYaStR1GHfErUeGHflZSIjNABYWA7HlnM/sfnsegPcXMWjUNtSZ1XW2/unUmpY6TquttljnUmrh/tlXDg4c7zpSkra0rqcFpVVcLAWnS1sGnSLnEQFEpqwPMTqseWgmHHwxR6BS+4AIqgEjBeVKLITuACblIvOkH68MrjGKhAvxXs8v2QCG5QXwsDY+kooMbEylTNlIuROjU8RJzlFGOInEZQpC3pEQkkHMSjTsVtpEUBWJv20Yj0EpsbekpuR7Sk9vaU2PHSUXItphlJ8T5iy5gRKoJ+gYc5Tq3GotKdYZDhxgt+yOLCLY+aWqCU2X3Hb6QhcgZSqmbWlVQM96V0vgDSulgAZ0mlmZ0mkDa5nS6QCPlOkUhd3adKQIFLe5bhOlI4w4MInSUwNSs950ukGw4cNuE6SjMyhcp0gYsNi3FJ0sYwrWM6WAtg5uOJ1hvmc/2QMlG1Aw9RKNpWcSqplIGdHeAj3jte29eVWx8rSq1sQ0HCVH1PDhwjuThFsuMZjmLXhOLPFHbFyjVLWEZ/q19I9S3GF/qFvbjC1uN4KgbzR6h0gqWsYjYiosb6H9kpivKJlJ5TeU3iPA8vC0SV8vUSqsdYRDDDsMMMMMMMMMM4v+x+WwbjNhBmEYHKG54iAAp9VzF34ou+ljAtwLnOJ9JI14iLuYgLwCwiZKT/GsXdgFl1JNou4hsT33Gr+x+WwjC9Qgx0uOlk3xARlxh0OtsWESvjfLehpkLiIZ2viYwoKzKhYBssjGDb7CmuICPfBWTKM/VpmEcgYnhUdX14qC/F44KHCQynMwIaBcYhV+uPuKwwD899939j8tj2wKSFlU9aUVyOFmlQmz9W/vKZsQCDLh6QQge8fDi4x6ueK6kZiUzgsWiELxMBZEOsYjCjNLl6jMCP8AGJnYEwlTn8iFsbM4CjkkWyEjOG4U27r7v7Jvv0iqzF1vVohHDKFrvVFRoWy6OUMdwHo0l04pMT0h+DKr1MBa7sIW/wDHdPyZjBaklwbWjEWqF1OG97iU0CAMCVXPOVHKUy5L25zIOgu+DK4MOjgiXFNUf5eYgxUcJozd190/tFiR4L7p/Y6kmUX+JRf4lF/iUXlF5ReUHlF/iUX+JRf4lF/iUX+JRf4lF/iUX+JRf4lF5ReUXlB5QeUWike47P3T+x+R2VFUnS86SkcMvMba6YtLdmqqmNdSNRDZRqTKqtbkdtZQw4Ew37CBvcTceLY7funu2/iMfiMf1r1218JMJdQ0QxSrzrceOIxMUm41iMCTEe4NpxSIWIWXwYc51l8OeKKXMUo863HEYhllNjB6Edgexmq7Pun9j+u2ooUwgsDFB3J5iJ92eQRN/BrPPPuz7cUY5wWfameZM6QFOK+Cek8kQY8U8w7PFdn3T+gXiH+IhimwiHKKcgP5inOKYp/iBpeXl5eXl5eGNDfwnM7EZojhfaA4gRFvu5xCAkpNbrJTJGATI4AJSbEHJEotiZgTKZaySkcGosIu/UEQqClpSLBTcSmVGK5lIkRGNklNsYaIVJI7f3T2+HZaVJUh8BpLymx5GAhVzNotQoTYERGOICzSm5KakwOCgJMpORjw4TEqDrIjjBxiPZSBylNzj0Mp1L04rzFKhEsQdvHwnmO0wi7c46ZjYeyewdh2n+e3909yYIOwINg71rCxlUSvfluXtGXq+A6sxxgvoKcrqD6pOkKPZZ0hL8dyV1t/hOkKNP7ZXUj/ABldbE5DBH4D+yVb213JVIW9/o4TpHDyS7wAAeH8+xGYYXyEVgRhOExRgTo4qTDZzFUU6bOPU4YFw1QcNuERTRZysClErZ3mn/HDQLgr6W4REFNQ4irepTDZy2P/AJBUQoSnFdDNOreImA1Chif08EZGDIW3eERTTqac1hVlDGYBakGN4qhqrMpvwKy2Km4Fxs+lBYbPu/oFopsdCJTLnnpEqIQRa0pEWlBjl/Mpld28G5FJlM3vBhUTHimIhoGaJfLd9JRP0jMc4GVrDLh4fz7DkgMbcqCH+pdV/wARCmGiYRvu5+Zhw0QcNuMdRSDk4hrYwj/tcEQ7poBDMOChpbjCLuWt+ZhL0UCm8ZcZrCoswC+iqMhCLIrg/mMLiqWh3XwC8FNVCFbKPqjqKdPy6tCuCpmpmAnqwhvH/pMWb1xRhhdw0Pu237p74eBNgxtLtT5iCMRHvbTOE/Oy/ZYKOcrrKy3MrKRKyZrHS40FuUqU89ctI6X9uXhRcK8SpEqRHiPA8DwPA8DwPA8DwPA8DxHiPEeK8SpEeU3lGVDbkOx93unjIZSUyiIKayqL8hNfXv8AzCfzKIB5iVpRb3XOMRDApylBTbUygJ0cSis6Ot50YToonRsjkROji5M6PZrcJ0cSgsuIdG8H5vGfd7k25n2nH/4ILwbEEA2cfB0lb3EQrOkNN8TEDGMMcgjTOOb+8c/McxjlHIjmE22cR4PzbOMvibIQkhmC2hh2NOBPbAsIL1As46y+JshM0cw+57f3e3kNrAACGXl41o4lppwM3oc+XeayrKkqSrKsqyrKss34lMSmIgiLEWIsRYi/ERfiInxEX4iqN3wfmGw2aNdU+mZnrgxnOcaE+3PMZ5zBBsEGyoVB1mZNOcEnOcKonOcaOwGWwMbbfu9nXnMzs1h1hh2nsGXB5ifhu757FyN7fiLrBrF4X1i/VpFyGsXKJwg01mV9O68o8LpqZZTotxpKoYhxeZ4pkRSCw3OCxmViSZmC5mHEvSMP08Ig6zrV4cDB/aIg6k9Hzy4xCUZGuAMjAoDrs+3DYEETRGzhzxgyxLWIhscBWfaYy2+WDZSmTaq0FiDpsviLFuxpMhy2fM17sbM1huCO557AbBT8wklrAi2lo7HM3vHbDhtbDCyjivK0JYFhaZMW0teM2QPDWbrcOOsJJHMad1yHhWIb0lapKrFeRlVgJUZpUZTKzEQ2I0Ijtmb/AJiYy+pvYwQlAECkA6yqwXlGJC6DZVe2yu0YsfWVGAjloSpjtu6ekrOIbk7PL2Ndmnfaz8w7h7nnsKnMWEtmpuLwKJhhB9IgP50lvccIylUxXvLD0vDuEj+Jhh0W3cenhdUpOwgvjw4bDJRKNz1BqE4uRlHEDUA1+kGUsfV/Sv5g4/62Ep23ULNzxShq7JryW8QlVpJn4Lls12az8nwOkOY07jn22sD+g8trnDyvlGNrEfgwBieJhsampjtva56wm9h/Edtb6x2sOF+U1bwPLZ7sZkBOPg/qXNfcTiO3xYTFMUDQNA0DQNA3zA0Vop+YpiGJEiS4lmHdDYdp7fl8bwF5qZxnHTwmjadvzjZWKgtOk9aAsR47qMQGUxsHYxWISK2HEBCyg3iPoBij1L5ZDSIXeBhYZiByA3GUWmjDaPfta9/5fGcFM47OM08JqpvOI7XmGw2XFK5YlJhzTKadcJ53iAHCI291s5mWxBc5ySczKFiEzeecS39WeXb5e1w7/wAvjBv4wAdnDw2nb8w2IcRiHGUIlIg3yibl7xMk0g3LWtKUTJNBKWYib40MS7RAFOsp7hzIlLcve0FgNBt8uzn2ND2DDCIRD2/Ie81MtCJaa95znIzifD+3a8w2Xt11g1/WIMSFr/4iYbGizYZgBwFzAoVQmK//ALw5OHs3EEQA2pB2JgXAig+9xLBVwX53aJuYyph0pMbGYDekrxLqHCkQqFIew4gCWZhQQ39yYylsSDF/lCCVcrcTU67OfZHfeQ+N4+I1JF+1piEYS1sWLXjGTeUKLHhORGvOcJaWy0z5y26LazDva5y3zymHFrrCt7W15x0UmwP+IhTF7zBn684U+m2vCWNs8ouEE3J28+8Hb8h73U7OU1Pe8fEZm4ufBi8EU/EFvx2efg/Ie805zQDZxmnecpwE4+H1Ok5Dt08RnR8N+OUQExQG17ixaDPEJTDRMNtose4aEexlG/sZQqfEo1P9ZRaZdvynwGk0Ond+XxG8YbzkO2qgBdZrhE8onlEUk4wICChinEKeK8GUS1nwmAA4wLXikW1i5xSFBFrwi2IabEBLkiIAUcAGch2+AygtpsJl5eHuPKfA8+78o2gY+MRWgZZVU98wEa/sIn5McnYeAPzOQ7aYlgCiKGEACwCwbFFG/qeUYE4LfTnNIoGFr5cYiizXmsCywECnZbc0lt5rmKmfZzMzvDduJt2jDM1mh7PlPejsc+78g7CZWF7eglSyNbBeWsk60XzEqkwKZSEomUjKbxHlNpRiLCBC4B46TP322ueZmohuMh3DjMCwgF+OUAF2EteAYQsIW81w9/8AM15wwTTuM0aadjkZzPgOfd+Ubeca45HSUw66hRlaG1Q/TyAMqp1hXUZCwih6bPdVHBbxEIGH/qBlEYt1SqnJS0pnrUcDXWE9aPrz0hupQG57P3FhxK72XO+GEa2uYcSsAL2taaLlPMIb72sQKMQyH6TpM15zTbyM8x7rkO1z7vyjbUsxiXHMQEe+0m3K8azc5V3iLEx8vTIzDbibZmcFA+OzfCrAm0UkVmyU8pZULXjkzUzTFDljnnGXj9e807HM91yHa593y2c9lK4B1EQFW5iUo7iVhChlL4MoNKDyi8oPKDSjAglVRK5lUNBYjYlyzCwM1xcJ5h4ARBNO80HfaEgHbzPdch2ufd8tnPZR6xSxvEAV7kpKJTFoZ0nj9BvKq5a58oQfY7KTE3AvsVyb7L5Siy2mUN/bbk67Liy/3TLfnFx4D8bNfFcO98o7XPu+XYoEq5i2BxTgFnmjlQcVzHNlCCVGAxLlDY4haVi29Yxt3rZVwANMTJY78cm1NpWayTnt8pgBz4zDibQcobtj1nnA7/QbdR+ji94bRxHEcR+/5T+4EgEcol1S9wJfEM7SqMzMOA4pTLDKUGXE6mU2IDRTYvNOtinDiMZuoCtaKwvTMpMCVGGJhJI2+UzjAhss85n3B/HguR7zgf0/kYxuKRIgG+HIPoogP0YmaG2EAm/Iw3Dthh+u9tlgSZZS38wC/tApPrMhLW9NmdnCmPmAZe4UHMWyM1fIbLWC5zzZQ5Bh4Ll3mp/RqNw6ktnDdbAjuKZGFpVXEykXIjlSikYh6xvqpBImaoi2vrhlAgGvBbC1W0qOS3RnZ8+IjszMCTficMqs5bGSDCcLhrgmHNaDysWxdFZiI1sNJSpvbWFsfWrhtkbWiZjpQvlEIKK4JPEtCAppIvxMlGg2cUzuBPOZnvHaYYe659++cIPZMPZMEO3Ww/nwtPEMEu/WNiD+nKE74Yi3ArMRKlNRlvT+xzjHpw2cht8xlI4ZVYehgVpRaFhKyR6WeuYhQ4dM4q3gUGAE2trzhRThwg8hHpnCAMyJWpXj39hKZj39OG04Thtcm8Nzj1moY4jz8FyPc8Ts9oRaBhfS0qGEGIspRIkSARoT87OE5nb5U/8AnhXuiRzhY3w8BGIEc6Djyg11PPZyGzjPMYtlp6mICAolLAyGViC8NwdD2SZeKwDaRbxLAyoqYodv0g5z/qDjXUw33ouZJ7XAX7kxoYe7F7GA25ERcxqQZcHnaWG9y1mHXnM97IgzQE7QL4QZpDecADOJEvt/vpL39Zg7Ji+nKVXu3lW8qvv5gBZWYGrpux82dlPphnSLkOFIIj1sQyvhylSpjRb5rHswBwrDVOYFstZTrOSgOIaDZ5Rt85mEuVn9TImc3nnWc+1QxsWyM88NjghvfBMh1s1IjIN0wW3RDYQf22mV3PGZgEi/a4JOQ7+92YjKHQ9jhfZxMoYwADKWsqEMOEqiMkt8wD5gX5hUSooawH4hxAbL5gWnPsaogI79v+s0gMQ1DCdLwYAQRaVcxiDQ3TCRUjlgHe/s0q47sCu7pnOlth1wWjHqnUYeYMS6BbFpe/W4h7SrVBwAYRps8g2+YypplkdI92tY34iUgl5dWSXKpChANMCUkKmu2KUw2FGIWUs8CHByxSjc9bhE808xhGLCRCC4wSuowMGn0JE4v8PFUW4gZzmIRhwG8+5NST2vIZw078jIkkQ3XlbSCDPgex5jHdchZllU3QrhAMK4hglNb1Wm71TgXER1YoSGJjPUZnKqIKlNhUCkSiT1epgtiF7bMsUy0znM6TiBt0wT6Tmva6PUcspJIaYdCwTVsMK56C+c+yHbEYwBRQRMFz6wA4CL2POBcstYBYgxcoBfAH14GBbe8JxdYFn0hVJZjMORI11IhIVAS0xAqwUqTzmEoXsbGWwsHIPILs8o2+cy/wBYZvWIuLhbK97xiMAEdIoI01mRf+CIFuGOozE1ZSLyq+LnflHJF75mEg+kdmtzMJHtDB2PMIi4gmjmfcF4OfazBSZEd1rCo43vGWwhWEfPKOoLDSWOI2uI6grHGnr2PMYBkTqIVbEQwGlozL1jAmVcL09CRHQmtaFNymVFpYvScm0ZcXWhrcgIVAqfTDcqoGzgIcrgw2NzMtNvkn1rmsFiDn2SwKKQYjdclIoJwQCBr9QEmIBqQWA2NMKDygYoaYVozBg5YG15fcNTF+ZjxohULMePqMBEuzFQBcS4GMMCIXAOEDjcLLoMZYWEF1YEERWw9YrMfaKf65f8GEYnc4PQNs8o2+c7DYiNm4FzGuMNoMhEIcMbG+U0LHuBeA6D+ZkwF7GNkLEzIY4UNkNou8awuxmef/729DmJ8dyJdSVtlDfMk5QGwItaA4rEQtugZRScJNomZTDMQIW23SC+ItGwsecK4eEDYcWgMubEGcmztyAM0AO7LA4jf2EWZHDeE352h5EAzMkjKHLIQcTNctvl2De/uHifKNnOeY9wueJN70JlIcsPLMjFHIsxA/AvAWOPW3AykMWZxEQkMfgQYQx0J5Ew4cSstx9IxCb1iLethENwuh5SoEUreZ74liAkyxVM4dWCjt/Wmw2mRnMTRRoBCSb2EHAaesB0UZesJBtCczASOUuRzn0mLq5tst9e9flBxJBv6z1HY/8AaIrZG4jMCx4HSVCbSxiCURKU6PfIyiotcTCDCSZkZm1xmeZnAm/Y8s4AmL/1DWLrqnYFzFK32CC21C3aFtgsfXbw2eUbfMe4Mdr2tGIGf8x2lVgpciwFxHc4mGY0ELkqQMyImPEVGd4gC8TbL5Me6lAgA1gYjAFl8IN5kGpnKE4i2QOk167uM0bXaYDfmIxlWVP55Sp/MqZe8f8AmVP5jjL1lT+ZUjxxGuo7H/vN1kHzCLhrkQmw5epj5ZxtYVtzhGpyhsoGQEptvOZkCt5fIjWCxxTO7rPOexynESrZDrNFm7UiEEbNcJtM1x6GIBdDpzEp5no5JlPGVRbLKd7FcuWKJliGfKXvjOK0t1iuCx9IgC4jKIU3YYedpS+stdvLaU97SU8Zuot+ILBczCDqDaU8ObZRBkgNrRRminZ5ROezzHtra+zXltAtiJPrcSkl00MvbFiv6yobmnew95omoJiHE1MP1kzAu0tbFeMqjAbmc5xqOe2T6wN1Nt6/EwXTZoYCvqY0Ols4/tDcEXMUoQDrxtKnO5tHzzvGyBENuQtBvHNY3vH9oeA7HDFBux7Yo4u0N9coMrRBh5QDImU1gFrk2h3oxme8J90TzNOfYMO1LiNiHKKykRzcaRzlpHN9I5vpGOesY52v+I5F+UF3fLFeMbRzcaRznrHOlo5EY56zMX0gIw8zzjGE7PKNvM9rmP4llXDZGte3vBZcRJymA7xN7esNK13LNaAZPawGqnjMNiRfLgLzQg6L9EB4WPsJT3woXF6A3gAVo5wiE5ieYQZWIEs+EHQ5zRVPa5bLbDgeIQRxjZiNrGj+sOa6TNsJC+l42keNHyMfTSC1uMJmfY4Az8bDG2NqTr6Q3BOojiVR6x4hY5jSLbMZe041DDqTBsFx3CBpdI6tKJlJviI0ptKbSm0RviI3xEaI0RojRGiH4imA7PKNvBj2KeIuWv6Whyh4jIRDvaRSLAX/ADGUXBIUnMxTeId7SI2topDZWHvBYmPZQQAY/rYRf79eOxb2BmQY3i/mG57Rw85UHxKv8Sr/ABKv8RwR6rsqytK0rSsZWMrGVjK0rSrK0qx9vlnAzXsGHK4ltYtzEOvKU5lnnB/cc5ncHsJY+hmL5hb5hb5hb5mL/aFvmYv9pj/2MLfJmL/aYvmBv9pi+Zj/ANpj/wBpj+YH/wBpj/2gf/aY/mY/mY/mYvmYvmAxOwd+IRtcgGWIEpjUGUziyxG/ITFcKBrrFbGi4RY5TihxEcyIG4ZcsMDaAa8jrKZzK3ES27YXN7EzMjSObcttMx8XpAAPTx3lG3SKRcWgtY5wCIIoi5WtEhtsOQB/mDTnNP0ES1vWUB7iVY6mUSZRcfiKR+Nph2CUmP4lIxlWVbygDMv0D6htp3NomUFjLWUQwwXDEWiA+syh1AimH9D0mnYMURF+JST4lFPiUk+Iq/Et8dvX9AS8usexjqYFifzKcQSwldZVYxNP0TSG3YOwmGG3ZPY4foHCG22kCZTIHoJeA3lxG/McEQ2nzMxzmY/Qfjsadodg3gHb0EyHi+J2tBD2L3gyiTKHZpPmfPj9Z+VhseIi3ht6GZwW7IhtD2jaD8w7MhNAfF8JrDM9t4Y0MMBgmUMEzmZ5TU+O1EymR5zOZR4BMoYIpl4YYZnFMEO0bdfGZGDLnDsFobwSmDKMoiJhFtjCb3rMoJmf0ATMQW2C3tKh/Mp/BmUOwCIIkSD+YIBDLnZnMh+gLHMsYkvCYYTKjzGfcynCBLtBb9DEyhvEgIhjwr8QJFX5gWYYwH4lSEmJLCEmD9GAiCKIB+mqIsvLwmXl4IogH6t//8QAKxEAAgIABAYCAwADAQEAAAAAAAECERITITEDECAwMkFRYSJAUARSgUJx/9oACAECAQE/AErY4V7KMJhMJhMH2YPswGD7MBgMA1Tr+JqampbNT8j8j8i5FyLkxYxXWvKfl/Ei0nqOpbGBmBig0KLMJh0MCSowL5FFL2bMtCaZPy/iptbCnJC4sjOfwZxnGaPi3ujN+jNT9GYl6M1P0Q4i9ok7la/iRimtTDAwRMMBQizBBGCAoRZlxMqJlxMuJlxMuI1Uq/iQ2GknuKl7KvWxJfI0m9ykhUjEha9MvJ/xIbDimYFVCikYEKCMCFBIwISrpl5P+Ip0jMZmMzGZjMxmYzMZmMzGZjM1imnyl5PoSk9kZc/gyp/A+HNehprf+RdakXaJeXOCuSQkloWWWOMXucWCjLTqboxxMcTFExRMUTHH5Mcfkxx+THH5E09n+xDxJeXOLwuyPGg9xOL2ZS/2NF/6HOCW5xJqT06mlWpUPRUT8D8D8BKDKgNQJVehF1JfrpNiVKiXl02zEzE+w1aowSi7Q5TW6HLW2N36MTFKSLmKxp2NNMi7in2oRTWplxMETBEwRMETBEwRMuJgiYIihESS25S8v0dCov0OJgMBgMBgMuLQlSrtcPYnZctEYnsQbumXytEm0yTbdGJ7EG9bLXKXl35bFyb0LmXMuZcy5L2YpfJiZb+S38nD1j2uGSi2xwbMAo0OLGm0KLsatji27RgFFpGFrlPy78vEW/K3RT3NWNWNV0cPx7XDGm2NMpjTYk12Z+XbenQ1aMuRlSMuRlzMqRlyMqRlSHCSGcPx5Npbj43DW7M/h/IuPw37FOD2fRw+9Py7bVoi/XN9ripJkPFcv8icnKvRfNNrY4HHbeF8+H131z8u4lTvm+1xXciHguXG4DbtEuFNbowtH/BRkz/H4U1O2ufD6nyXU9+43XN6IzfozX8Gb9Gd9Gd9Gd9Ga/gzX8D4knyh4Lm0mOEHvEy4fAoxW0eiHU3yT6WPfuNc3syFW7KJq3SMDFFscWi2oktYig3qNU6IeC7UN+l7c10se4lqUjCYGYJGCRgkYJGBmApIk+b2E2mXLex3d2NtIxNKhtsxSqrHKTVMtjbe5DwXa4e/S9ua36WPcToVMoplSFaevN3eg1Jj2Hzez7cPBdrh79L25rfoYx7j5JsxMxsxsxsxsxMUmNj5vYfQtWS6YaRXahv0splMS16GMe4+ytxj5y8WPoS0GtOlbLsXyg6fbTGxj3KsrsRVsZLnLxfSth7dC3FsNpblrk+bkkOa9CE6didq+1TsafJ7i3LPxMKZgMBgMKXsSjZVEiXN7D6E6G+hbi2J+R/8YnL0xykvZjkNz+SmyKFyhKmJ3qullyseMuR+R+TFdaj3EUUxNpCloYrH5D3EnYrvUkPm9iSal1qitRKmhcnGL9GXEyoi4URwi0JVaIi5qTQppn5IeKi5FyLkXIbdlyZqK61HuJ0Va0KZqJFIopGg2hsfROGJDVOn0JRa1KgVEqKEliXK1dFrobS3LTbZHqU2nVmbRmj4yRmmaZg+J6MYppj3ErRF1pzasp0O0tS/vmx9MoKQ+G0VT1Rp/qX9H/D/AIK/gXkuTrG7JfRc0YprcTbq2NTb3IoS6pQk22jKns2LhT+TBKjLm3uLhTvcy5fI4SbtMUJvVshFrlEapilW4pJlmIbv0X9Fi12Y9x9U1Ju0YeK/YoyrVmGfpmDifJhnW4lxHuxR015TV6otDk9kPEz8xKXtkVQt/wBGLpjSZOL9DzEJzsc5pmPifAnxH6K4rdNnDTjo2Nobvvp1Jpk4XqjAzCzUdoVVYnb0/Stlv9iULdoSlsxQS9jh9mD7MCQuEKKW38tf17L/AJ9cq/rf/8QAKxEAAgIABQQCAgICAwAAAAAAAAECEQMQEiExEyAwUTJBFFBAUiJhI0Jw/9oACAEDAQE/ABPKyy8rLLLLLL/TbZ7GxsbGxSNjYeS4/SNWcFlllllllsbeVDFx+kWVI0o0mk0mk0mk0lFDRwv0llstlstlstlstlstlstlv9K/BX6pllllllll931+kqyiiiiiiiiiihrJcdjlFcs6sPZ1oexYsH9iafD/AFLFxnN1Fsbk3uUUUJyXDMGblHfuSbdIeHNfRol6NEvRol6OnL0dKfo6U/R0p+jpz9DhJcrxrysXGbVqieBNPYcZrlCfuJzxEWHN/RhwcFv3Ju9hvFLmf8jKxPUisQbxEa8T2J45hp6d+TEinBoap+JeSxsXHbSNMfQkvXgi6lZ1oYkaewsPDfEhYdKkxQp7s6a9k8ODRow7Ho5RGaSE1JMxFU2vE3QmzUy2Wy2ajUy2ajUxtl5Ljw337ibQp4i4YsWfs60zrTOrIeLI6shY80ycnKTb8TEUikNFFFCWwlsUhorJceeCuSRpw0t0JYT+isI04XorCFGD4Roh6NEf6mmPo0x9GMkp7eJidCZY2WWi0J0JljZeS488PmiaWkVIaSZaexsthT0qqE7V9mN834mXsWWi0Pwrjxrfsi6kmdeJ14HXgdeHo68DrwOvE/IiRxoMTMb5vJK+BYc39HRn6HhT9DjJcrsfmXAvEnTJpbNZrxYEm40zF+bywYJRTfY0nyY2FFK1m/MheNu41mvFgJqFsxfm8sLGSjTFOD4Zzwzf2Npcsxpx00s35l5Em80rdHQXs6C9iwF7Px/9n4/+z8dezoR4sWBH2RwYIWxi/N5fQm0apL7NcvY2399j8qF5E84fJGLdKi+EYc6i7FixY8RJ0xTT2RVy2ZDaaHipOiLtWYvzfiflWdlllllotFl5Rzj8kTSaSaKitnAVVWkUU3xQ8OLdsUYrgUIJ3QoRTtI0R9CSXBi/N+J/w9jbNZxzj8kLjxYnzfifnWVFFFFFIpDQiOcfkhcdk9kYbb57cT5vxPjyIXkRHOHyQuOybbZF0+xkncn4nx468rYiPGcPkhdk/kxcizfA+WJN8IprntUZPhCwZcsapjGq8X13bllllllvJEeM4/JC47HBt2LDdnGb4Y+TDf8Ahtyb1vCyofcBQw26o6UF9CUPRcVwTk7G98mrH2o2KRSNjbN5WclFH1k3khcZp07MOSlFPvndbCbobbix8i2FOa4YsaaFjyHjzFiyTNSaTJ8jzasao2KRSKRsUjY28Fl9iQhcCzwcTQ6fAmpK12Tc09huZcxObLlodjNMqsp9iTbpCVJJk3yPto02aRRNJpNJpKKYsn2WLsQu2GJKDOqpO7otNbTKf9yn/cS9zEq/7jSv5jtQe4xJvDVEOXqEsJ/RownwNJXSIuEUnW5N20yTtPuTRqiakJ7lpFotCaG0N3kxMoooorKskLuVCaHItFotWNoU2tllhOtmKD9iglbYlBC6ZqhWyJu2qJcee8mITRsNIpFIpI2QxIS87g3BSX0YeNWzOqrHNNVR/iKnwSTuiaqNvz1nRXgX8CGLpVMk4PdFmo1Ck7Hj7bIlOUuf4dlll/8Amn//2Q==)
موارد مصرف اپیروبیسین:
اپی روبیسین در درمان سرطان سینه، مثانه، میلوم مولتیپل، لنفوم ها، لوسمی های حاد، سرطان رحم، تخمدان، پروستات و دستگاه گوارش مصرف شده است.
مکانیسم اثر اپیروبیسین:
اپی روبیسین از دسته آنتی بیوتیک های ضد سرطان است و احتمالاً از طریق اتصال به DNA مانع ساخت اسیدهای هسته ای می شود.
فارماکوکینتیک اپیروبیسین:
اپی روبیسین توسط کبد متابولیزه شده و عمدتاً از طریق صفرا دفع می شود. نیمه عمر دارو40-30 ساعت است و از سد خونی – مغزی نیز عبور نمی کند.
عوارض جانبی اپیروبیسین:
لکوپنی یا عفونت، التهاب مخاط دهان و التهاب ریوی از عوارض جانبی شایع دارو هستند.
تداخلات دارویی اپیروبیسین:
این دارو با آلوپورینول، کلشی سین، سایر داروهای تضعیف کننده مغز استخوان، رادیوتراپی و دانوروبیسین تداخل دارد.
توصیه های دارویی اپیروبیسین:
- اپی روبیسین نباید در بیمارانی که قبلاً مقادیر تجمعی کامل اپی روبیسین و دانوروبیسین را دریافت کرده اند، مصرف شود.
- با مصرف اپی روبیسین در فواصل یک هفته ای ممکن است خطر عوارض جانبی قلبی و خونی کمتر شود.
- اپی روبیسین را باید به صورت تزریق وریدی آهسته تجویز کرد . به علت تحریک ورید در محل تزریق و احتمال خطر بروز ترومبوفلبیت و نشت دارو به بافتهای اطراف رگ، انفوزیون وریدی دارو توصیه نمی شود.
- اپی روبیسین موجب نکروز موضعی بافتها می شود به همین دلیل به صورت عضلانی یا زیر جلدی نباید تزریق شود.