اتوپوزاید
Etoposide
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موارد مصرف اتوپوزاید:
اتوپوزید در درمان کارسینوم ریه و بیضه به کار می رود. همچنین در درمان کارسینوم مثانه، لنفوم های هوچکینی و غیر هوچکینی، لوسمی حاد میلوسیتیک، سارکوم اوینگ وکاپوسی مصرف شده است.
مکانیسم اثر اتوپوزاید:
اتوپوزید مهار کننده آنزیم توپوایزومراز II است و با اثر بر مرحله قبل از میتوز تقسیم سلولی، ساخت DNA را مهار می کند.
فارماکوکینتیک اتوپوزاید:
فراهمی زیستی فرم خوراکی حدود 50 در صد است. انتشار آن در مایع مغزی – نخاعی متغییر و کم است. متابولیسم دارو کبدی بوده و نیمه عمر آن حدود 7 ساعت می باشد. دارو به طور عمده از طریق کلیه دفع می شود.
عوارض جانبی اتوپوزاید:
کم خونی، کاهش گلبول های سفید یا پلاکت های خون، آنافیلاکسی، استئوماتیت، کاهش اشتها، تهوع و استفراغ از عوارض جانبی مهم و نسبتاض شایع دارو می باشند.
هشدارهای اتوپوزاید:
قبل از هر بار مصرف خوراکی دارو، دهان از نظر وجود زخم بررسی شود.
توصیه های دارویی اتوپوزاید:
- در مورد شکل تزریقی، برای جلوگیری از افت فشار خون، تجویز دارو به صورت انفوزیون و در مدت بیش از 60-30 دقیقه انجام شود. از راه های دیگر تزریق یا تزریق سریع ورید خودداری شود.
- تعداد گرانولوسیت ها 14-7 روز پس از تجویز و تعداد پلاکت ها 16-9در روز بیستم به میزان طبیعی بر می گردد.